Kuraray Co., Ltd.

Taisho Pharmaceutical Co., Ltd.

National Institute of Advanced Industrial Science and Technology

Kurary Company, Ltd.

Cytopathfinder, Inc.

Manzo Shiono

Yoshiji Fujita

Goro Asanuma

Koichi Kanehira

Hideki Matsuda

Takashi Nishida

Johji Yamahara

Katsushi Eziri

Shigeki Kikuyama

Takanobu Shin

Yoshin Tamai

Yoshiaki Omura

Takehiro Amano

Michihiro Ishiguro

Kensei Yoshikawa

Tatsuhiko Hayashibara

Yutaka Ohuchi

Tatsuhiko Sano

Toshimichi Mitani

Yutaka Mizushima

Fumio Mori

Masahiro Torihara

Naoshi Nakagawa

Yoichi Ninagawa

Jiro Tsuji

Michio Terasawa

Toshitaka Ota

Tadakatsu Mandai

Rie Igarashi

Tomoya Kuwayama

Noriyuki Yamamoto

Masahisa Tanomura

Takashi Takahashi

Hirofusa Ajioka

Kenzo Arizono

Masahito Komuro

Masayuki Inoue

Tadashi Hatanaka

Shigeo Ohzono

Makoto Nakazawa

Keiko Hoshi

Kazuya Takaki

Shinichi Inoue

Shigeo Oozono

Kenji Tasaka

Yoichi Satake

Fumito Yamamoto

Kaoru Nomoto

Hiroshi Ozasa

Masakatsu Hato

A cubic liquid crystal composition comprising at least one amphiphilic compound having the following general formula (1) and having an IV/OV value of 0.65 to 0.95, and water or an aqueous medium: 

Type II cubic liquid crystal composition

Method for producing pyridine derivatives

A pyridine alcohol derivative represented by General Formula III

Process for the preparation of 2-chloro-5-chloromethyl-1,3-thiazole

A cyclopropylacetylene derivative of the formula (V):

Process for the preparation of cyclopropylacetylene derivatives

Process for preparing halogenopyridine derivatives

A pyridine alcohol derivative represented by General Formula III ##STR1## (where A represents a divalent organic group which may contain one to three oxygen atoms, nitrogen atoms and/or sulfur atoms, wherein A may form a 5-, 6-, 7-, or 8-membered ring together with two bonded carbon atoms, where said ring may form a condensed ring with one or more additional rings; R.sup.5 represents a hydrogen atom, --CHR.sup.1 R.sup.2, or an alkenyl group, an aryl group or an aralkyl group which may be substituted; R.sup.1 and R.sup.2 each independently represent a hydrogen atom or a hydrocarbon group which may be substituted; and R.sup.6 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group or an aralkyl group which may be substituted), is produced by:

Intermediates for producing pyridine derivatives

According to the present invention, provided are

A method for producing bromomethylcyclopropane is provided, comprising reacting an organic sulfonyl halide with cyclopropylmethanol in the presence of a tertiary amine in a non-protic solvent, to generate cyclopropylmethyl organic sulfonate, and reacting the resulting cyclopropylmethyl organic sulfonate with an alkali metal bromide and/or a quaternary ammonium bromide in a non-protic polar solvent.

Method for producing bromomethylcyclopropane

According to the present invention, a process for the preparation of a cyclopropylacetylene derivative represented by the following formula (III): ##STR1## is provided, which comprises reacting a cyclopropylacrylic acid derivative represented by the following formula (I): ##STR2## with a halogenating agent to obtain a halogenocyclopropylpropionic acid derivative represented by the following formula (II): ##STR3## and reacting the halogenocyclopropylpropionic acid derivative with a base.

A process for producing an optically active olefin represented by a formula ##STR1## wherein R.sup.1 represents an organic group and X represents a polycyclic carbon ring group, by reacting a corresponding optically active ester derivative represented by a formula ##STR2## wherein R.sup.1 and X are as defined above and R represents a hydrogen atom, an alkoxy group, an alkenyloxy group or a substituted or unsubstituted aralkyloxy group, with formic acid or a salt thereof in the presence of a catalyst comprising a palladium salt and a tertiary phosphine. Said process makes it possible to produce, at a high yield at a high selectivity, an optically active olefin which has a physiological activity and is useful as a medicine or is useful as an intermediate for the synthesis of physiologically active steroids. Further, said process uses no harmful reagent such as mercury or the like. Thus, it is advantageous as an industrial process.

Process for producing optically active olefin

1-amino-2-cyclohexene compounds represented by the following formula (I): ##STR1## wherein the substituents are as defined in the specification, a process for preparing the compounds and their use as intermediates in the production of medicinal and agricultural agents is disclosed.

1-amino-2-cyclohexene derivative and production process therefor

Novel terpene amino alcohols having an antiallergic activity or an activity of improving cerebral function are provided. Also provided are medicinal uses of the alcohols.

Terpene amino alcohols and medicinal uses thereof

Growing community of inventors

Chiyoda-ku, Japan

Manzo Shiono