Greenovation Biotech Gmbh

Meridian Biopharmaceuticals Gmbh

Manuela Loidl

Hans Loibner

Gottfried Himmler

Manfred Schuster

Geert Mudde

Gerda Redl

Guenter Waxenecker

The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.

Method of treating lewis Y-expressing tumors

The invention relates to a monoclonal antibody, or fragment of the antibody, that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region of the antibody, or fragment of the antibody, carries a bi-sected hybrid type N-glycosylation pattern and that the antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.

N-glycosylated antibody

Growing community of inventors

Korneuburg, Austria

Manuela Loidl