Intercell Ag

Arsanis Biosciences Gmbh

Manuel Zerbs

Eszter Nagy

Astrid Teubenbacher

Andreas Meinke

Markus Hanner

Alexander Von Gabain

Jutta Pikalo

Bianka Prinz

Gábor Nagy

Irina Mirkina

Adriana Badarau

Zoltán Magyarics

Beatrice Senn

Zehra Visram

Beatrice Tschanun

Carmen Giefing-Krōll

Carmen Giefing

Michaela Jaegerhofer

Michael Benjamin Battles

Ivana Dolezilkova

Lukas Stulik

Harald Rouha

Bianka Dominique Prinz

The subject relates to a cross-neutralizing antibody comprising at least one polyspecific binding site that binds to alpha-toxin (Hla) and at least one of the bi-component toxins of, its medical and diagnostic use, method of producing the antibody, including an isolated nucleotide sequence, plasmids and host cells as used in the production of the antibody; and further an isolated conformational epitope recognized by a specific cross-neutralizing antibody.

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The present invention relates to a protective peptide of() or a functionally active variant thereof; a composition comprising at least two of such peptides or variants; one or more nucleic acid(s) encoding such peptide or variant; a pharmaceutical composition comprising such peptide or variant, composition, or nucleic acid(s); a method of producing an antibody using such peptide or variant or composition; the use of such peptide or variant and/or composition and/or nucleic acid(s) for the manufacture of a medicament; a method of diagnosing ainfection using such peptide or variant, composition or a primer and/or probe specific for the nucleic acid(s); a method for identifying a ligand capable of binding to such peptide or variant; and the use of such peptide or variant for the isolation, purification and/or identification of an interaction partner of the peptide.

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Vienna, Austria

Manuel Zerbs