Centro De Ingenieria Genetica Y Biotecnologia

Manuel Selman-Housein Sosa

Luis Javier González López

Gerardo Enrique Guillén Nieto

Diana Garcia Del Barco Herrera

Lila Rosa Castellanos Serra

Jorge Victor Gavilondo Cowley

Danay Cibrian Vera

Mónica Bequet Romero

Ernesto Lopez Mola

Jorge Berlanga Acosta

Mariela Vazquez Castillo

Eduardo Martinez Diaz

Caridad Anais Gasmuri González

Raúl Gómez Riera

José Garcia Suárez

Gloria Véliz Rios

Jesús Reyes González

Maria Del Carmen Abrahantes Pérez

José Suarez Alba

María Del Carmen Calle 186 Abrahantes Perez

Jesús Calle 186 Reyes González

José Calle 186 García Suárez

Gloria Calle 140 Veliz Ríos

Eduardo Calle 186 Martínez Díaz

Luis Javier Calle 186 González López

Lila Rosa Kohly 51 Castellanos Serra

Jorge Victor Calle G Gavilondo Cowley

Diana García Del Barco Herrera

The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

Method for controlling fibrosis and other pathological deposits in tissues comprising administering a GHRP-6 composition

The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1-100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's 'in vivo' administration has antitumoral, antiangiogenic and protective effect against malignant tumors.

Pharmaceutical composition containing polypeptide fragments of serralysins

Growing community of inventors

Ciudad de la Habana, Cuba

Manuel Selman-Housein Sosa