Merck Sharp + Dohme Corp.

Manuel Scanu

Valdas Jurkauskas

Kristos Adrian Moshos

Giovanni Fogliato

You Seok Hwang

Michele Benotti

Described herein are crystalline forms of a compound of formula (III'), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.

Intermediates in the synthesis of cephalosporin compounds

Described herein are crystalline forms of a compound of formula (II&#x393;), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (II&#x393;): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.

Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.

Synthesis of cephalosporin compounds

This disclosure relates to an improved synthesis of cephalosporin antibiotic compounds such as ceftolozane, and compositions and methods of use thereof. Thiadiazolyl-oximinoacetic acid compounds such as TATD can be reacted to yield the activated thiadiazolyl-oximinoacetic acid methanesulfonate ester compounds useful in the manufacture of cephalosporin antibiotic compounds.

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Milan, Italy

Manuel Scanu