Tengion, Inc.

Wake Forest University

Inregen

Regenmedtx, LLC

Cedars-sinai Medical Center

Prokidney

Regenmed, Inc.

Manuel J Jayo

Timothy A Bertram

Oluwatoyin A Knight

Roger M Ilagan

Andrew T Bruce

John W Ludlow

Deepak Jain

Richard Payne

Namrata D Sangha

Sharon C Presnell

Russell W Kelley

Shay M Wallace

Sumana Choudhury

Joydeep Basu

Kelly Guthrie

Eric S Werdin

H Scott Rapoport

Darell McCoy

Christopher W Genheimer

Claude L Hughes, Jr

Craig R Halberstadt

Elias A Rivera

Bryan R Cox

Patricia D Tatsumi

Jessica J Reinsch

Benjamin Watts

Thomas Spencer

Neil F Robins

Sarah F Quinlan

Sarah A Boyd

Dominic M Justewicz

Wendy Sharp

Kelly I Guthrie

Russell W Keller

Darrell Mccoy

Scott H Rapoport

Jacob E Shokes

Teresa B Burnette

The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.

Bioactive renal cells

The present invention concerns bioactive renal cells populations, renal cell constructs, and methods of making and using the same.

The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.

Isolated renal cells and uses thereof

The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.

Cell scaffold constructs

Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.

Scaffolds for organ reconstruction and augmentation

Cell-scaffold constructs

Disclosed are methods and compositions for oral contraception and for hormone replacement therapy. Certain compositions of the invention contain androgens, preferably methyltestosterone to be taken in conjunction with estrogens and progestins.

Combined pharmaceutical estrogen-androgen-progestin

Disclosed are methods and compositions for oral contraception and hormonal therapy. Certain compositions and methods of the invention contain androgens, and preferably methyltestosterone to be combined with estrogen and progestin compositions in a hormonal component of a pharmaceutical composition.

Combined pharmaceutical estrogen-androgen-progestin oral contraceptive

Disclosed are methods and compositions for oral contraception. Certain compositions of the invention contain androgens, preferably methyltestosterone to be taken by younger users of the contraceptives to inhibit adverse effects of oral contraceptive use on bone mineral density.

Growing community of inventors

Winston-Salem, NC, United States of America

Manuel J Jayo