University of Saskatchewan

Ciba-geigy Canada Ltd.

Veterinary Infectious Disease Organization

Manuel Campos

Andrew A Potter

Huw P Hughes

Mark J Redmond

Gilbert G Matte

Deborah M Haines

New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of an RTX cytotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.

Vaccines with chimeric protein comprising gamma-interferon and

Chimeric protein comprising an RTX-family cytotoxin and interferon-2 or

Compositions and methods for preparing and delivering encapsulated biologically active agents to specific cell types are disclosed. Substances can be encapsulated in the VP6 inner capsid protein of rotavirus and delivered to selected cells, tissues and organs. Targeting agents can be linked to the surface of the VP6 sphere so that appropriate agents can be delivered to preselected cells and tissue types.

VP6 encapsulated drug delivery

Advantage is taken of the ability of rotaviral VP6 protein to home to macrophage and monocytes to provide label to these cells in either an in vitro or in vivo environment. Further, the ability to couple label to the VP6 protein and to couple VP6 to a targeting agent provides a mechanism for conducting label (or an effector moiety) to any desired target.

Rotavirus VP6 as a diagnostic and targeting agent

New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of leukotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.

Gamma-iterferon-leukotoxin gene fusions and uses thereof

Interleukin-2-leukotoxin gene fusions and uses thereof

Methods of treating diseases in swine are disclosed using porcine interferon alpha and/or gamma.

Growing community of inventors

Saskatoon, Canada

Manuel Campos