Cima Labs Inc.

Clexio Biosciences Ltd.

Manuel A Vega Zepeda

Victoria Ann O'Neill

Derek V Moe

Dinesh K Haswani

Randal A Seburg

Ehab Hamed

Walid A Habib

Victoria A O'neill

Described are immediate release oral dosage forms that contain abuse-deterrent features. In particular, the disclosed dosage forms provide deterrence of abuse by ingestion of multiple individual doses. In addition, the disclosed dosage forms provide protection from overdose in the event of accidental or intentional ingestion of multiple individual doses.

Immediate release abuse-deterrent granulated dosage forms

A pharmaceutical composition may include a coated particulate which may include at least one active pharmaceutical ingredient, particularly one susceptible to abuse by an individual. The coated particles may include a fat/wax and have improved controlled release and/or crush resistance. Method of making these coated particulate and dosage forms therewith are also described.

Abuse resistant drug formulation

The disclosure relates to a sustained-release oral dosage form for once-a-day administration comprising a matrix containing a viscosity modifier and coated granules containing hydromorphone. The dosage form can have a release profile such that 16 hours following administration, less than about 85 percent of the hydromorphone is released. In addition, the dosage form may have alcohol and/or crush resistance.

Abuse-resistant formulations

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Minnetonka, MN, United States of America

Manuel A Vega Zepeda