Tusker Medical, Inc.

Hospira, Inc.

Eksigent Technologies, LLC

Mansour A Saleki

Bernard H Andreas

Rohit Kulbhushan Girotra

Nikhil Bhat

Alfredo Cantu

Mahyar Zardoshti Kermani

Miranda M Ray

Shrirang V Ranade

Marwan A Fathallah

Robert P Cousineau

Robert R Boyd

Howard L Greene

Kent D Abrahamson

Brian A Kidd

Michael W Lawless

Lori E Lucke

David T Wang

Eric R Navin

Antonio Reis

Peter J Scaramuzzi

Benjamin T Mullin

Rohit Girotra

Howard A Greene

Nikhil D Bhat

Christopher Todd Brahana

Various systems and methods provide iontophoretic delivery of anesthesia at a patient's tympanic membrane. At least one example is a method including: performing iontophoresis within a first ear canal by driving, by a control unit, a DC signal to an electrode of a first iontophoresis device positioned within the first ear canal, the electrode at least partially submerged within an iontophoresis fluid within the first ear canal; measuring, by the control unit, a mixed capacitance associated with the electrode by driving a first AC signal having a first frequency to the electrode; and determining, based on a change in the mixed capacitance, that an air bubble is present in the iontophoresis fluid.

System and method for providing iontophoresis at tympanic membrane

Systems and methods are provided for sealing an ear canal for retaining a solution in the ear canal. Adhesive earplugs are provided through which the solution can be delivered, and which, following delivery, retain the fluid in the ear canal. The systems and methods may also be useful for delivering an anesthetizing solution to the ear canal of a human patient and for maintaining the solution therein for use with an iontophoresis system for anesthetizing the tympanic membrane.

Adhesive earplugs useful for sealing the ear canal

Systems and methods are provided for anesthetizing a tympanic membrane of an ear. The systems are personalizable to ensure proper anesthetizing solution administration. The systems and methods may also be useful for administering a solution to the ear canal of a human patient and for maintaining the solution therein.

Personalizable system and method for anesthetizing the tympanic membrane

Various systems and methods provide iontophoretic delivery of anesthesia at a patient's tympanic membrane. Some implementations provide channel switching enabling a single current sink to pull current through two electrodes in an alternating fashion based on clock pulses. The iontophoretic delivery of anesthesia may be driven by an AC modulated current. Some implementations provide for continuous flow of fresh iontophoresis fluid to the ear canal during iontophoresis. The fluid flows from a source reservoir into the cavity between the tympanic membrane and a plug, and then drains out of the cavity to a reservoir. An iontophoresis system may also detect capacitance between an anode electrode and an auxiliary electrode in a patient's ear canal, watching for reduced capacitance to indicate presence of a bubble in the iontophoresis fluid.

Systems and methods are described for administering a solution to a tympanic membrane of an ear canal of a subject. In some embodiments, the system includes a fluid delivery channel with a proximal end, a distal end, and a lumen defined therebetween. The proximal end can include at least one of a valve and Luer connector for selectively establishing fluid communication between a solution source and the lumen of the fluid delivery channel. The distal end can include an atraumatic tip defining a plurality of spray holes for providing fluid communication between the lumen and the ear canal. The atraumatic tip can be capable of being inserted into the ear canal and positioned near the tympanic membrane with the plurality of spray holes substantially facing the tympanic membrane to fill the ear canal with the solution from a portion near the tympanic membrane out toward an outer ear portion.

A medical pump with a closed loop stroke feedback system and method, for use with a pumping chamber, for example in a cassette, is disclosed. The pump includes a pumping element that intermittently pressurizes a pumping chamber during a pumping cycle. A pressure sensor detects the pressure exerted by the pumping element on the pumping chamber. A position sensor detects the position of the pumping element. A processing unit processes pressure data from the pressure sensor and position data from the position sensor to determine a calculated stroke volume of the pump for a pump cycle, and to adjust a stroke frequency of the pump to compensate for variation in the stroke volume.

Medical infusion pump with closed loop stroke feedback system and method

An electrokinetic pump and fluid delivery system is provided that may include any of a number of features. One feature of the fluid delivery system is that it can deliver a fixed volume of fluid with each stroke of the electrokinetic pump. Another feature of the fluid delivery system is that it can accurately deliver fluid at a target flow rate over time. Methods associated with use of the electrokinetic pump and fluid delivery system are also covered.

Electrokinetic pump with fixed stroke volume

A medical pump with an improved continuity low flow delivery system and method for use with a pumping chamber, for example in a cassette, is disclosed. The pump includes a pump drive for exerting a force on the pumping chamber and a sensor for sensing the force/pressure exerted by the pump drive on the pumping chamber. The pump drive position sensor senses the position of the pump drive. The medical pump also includes a processing unit and a memory having a programming code adapted to calculate the rate of change of the sensed force/pressure values and determine whether the rate of change of the sensed force/pressure values meets a rate of change threshold. Once the rate of change threshold is met, the programming code is adapted to calculate a remaining pump drive travel value for determining how much farther the pump drive should travel before the end of an effective pump cycle. The programming code is further adapted to trigger one or more signals to drive the pump drive for the remainder of the effective pump cycle using the remaining pump drive travel value.

System and method for improved low flow medical pump delivery

Growing community of inventors

San Jose, CA, United States of America

Mansour A Saleki