Pfizer Corporation

Agouron Pharmaceuticals, Inc.

Manoussos Perros

Anthony Wood

David Anthony Price

Blanda Luzia Christa Stammen

Duncan Robert Armour

Martin Paul Edwards

Paul Anthony Stupple

Charles Eric Mowbray

Blanda Luzia Stammen

Romuald Gaston Corbau

The present invention provides compounds of the formula: 

Tropane derivatives useful in therapy

The present invention provides compounds of the formula: wherein Ris Ccycloalkyl optionally substituted by one or more fluorine atoms, or Calkyl optionally substituted by one or more fluorine atoms, or Ccycloalkylmethyl optionally ring-substituted by one or more fluorine atoms; and

Compounds of Formula 1[R&#x3b1;]&#x2212;[R&#x3b2;]&#x2212;[R&#x3b3;]&#x2212;[R&#x3b4;] &#x2003;&#x2003;(I)which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and methods of treatment using these compounds.

CCR5 modulators

This invention relates to the use of pyrazole derivatives of the formula  and pharmaceutically acceptable salts and solvates thereof, in the manufacture of a reverse transcriptase inhibitor or modulator, to certain novel such pyrazole derivatives and to processes for the preparation of and compositions containing such novel derivatives.

Pyrazole derivatives

Compounds of Formula 1[R&#x3b1;]&#x2014;[R&#x3b2;]&#x2014;[R&#x3b3;]&#x2014;[R&#x3b4;]&#x2003;&#x2003;(1)which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and methods of treatment using these compounds.

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Sandwich, United Kingdom

Manoussos Perros