Lupin, Inc.

Lupin Atlantis Holdings Sa

Manojkumar Ramprasad Shukla

Venkata Poornapragnacharyulu Palle

Rajender Kumar Kamboj

Sanjeev Anant Kulkarni

Ankush Gangaram Sarde

Navnath Bajirao Walke

Mahadeo Bhaskar Tryambake

Rajeshkumar Maganlal Loriya

Talha Hussain Khan

Ramesh Dattatraya Phadtare

Vinod Dinkar Chaudhari

Vipul Dilip Pachpute

Majid Bashir Sayyed

Dronamraju Prameela

Milind Dattatraya Sindkhedkar

Prathap Sreedharan Nair

Samiron Phukan

Chetan Sanjay Pawar

Dipak Raychand Lagad

Sanjay Pralhad Kurhade

Nilesh Raghunath Khedkar

Sachin Sethi

Pradeep Rangrao Patil

Ganesh Navinchandra Gote

Prashant Popatrao Vidhate

Sachin Jaysing Mahangare

Nirmal Kumar Jana

Pachpute Dilip Vipul

Sarde Gangaram Ankush

Anand Jagannath Tarage

Dagadu Dube

Vikas Sitaram Tambe

Pradip Balu Wagh

Sudhakar Maruti Balgude

Ganesh Kakade

Venkata P Palle

Vipul Pachpute

Sachin Mahangare

Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, Rto R, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.

Substituted tricyclic compounds

The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention. 

Substituted chroman compounds as calcium sensing receptor modulators

Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R-R, and n are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PI3K enzyme of a subject. 

Quinolizinone derivatives as PI3K inhibitors

The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention. (Formula I) 

Arylalkylamine compounds as calcium sensing receptor modulators

Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors of Formula (I). 

Benzo [B] [1,4] oxazin derivatives as calcium sensing receptor modulators

Substituted morpholines as modulators for the calcium sensing receptor

The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention. 

Growing community of inventors

Pune, India

Manojkumar Ramprasad Shukla