Wockhardt Limited

Wockhardt Research Centre

Manoj Mashalkar

Girish Kumar Jain

Munish Talwar

Ritesh Kapoor

Mandar Kodgule

Sanjay Mate

Yatendra Kumar Gupta

There is provided an extended release pharmaceutical composition comprising from about 200 mg to about 1000 mg of entacapone or salts thereof, optionally with other pharmaceutically acceptable excipients. The invention also provides an extended release pharmaceutical composition comprising triple combination of from about 30 mg to about 300 mg of levodopa, 10 mg to about 100 mg of carbidopa and 200 mg to about 1000 mg of entacapone or salts thereof, optionally with other pharmaceutically acceptable excipients. The invention also relates to process of preparation of such compositions.

Extended release pharmaceutical composition of entacapone or salts thereof

The present invention relates to single oral dose pharmaceutical compositions comprising a combination of entacapone, levodopa and carbidopa, or salts thereof along with one or more sugar alcohols, wherein the entacapone is co-micronized with one or more sugar alcohols. The composition of the invention exhibits bioequivalence to commercially available entacapone, levodopa and carbidopa combination formulation marketed under the trade name Stalevo200&#xae;. The invention also relates to processes for making such compositions.

Pharmaceutical compositions of entacapone, levodopa and carbidopa with improved bioavailability

There is provided a single unit oral dose pharmaceutical composition comprising a) levodopa or salts thereof from about 50 mg to about 300 mg in extended release form, b) carbidopa or salts thereof from about 10 mg to about 100 mg in extended release and c) entacapone or salts thereof from about 100 mg to about 1000 mg in immediate release form, optionally with other pharmaceutically acceptable excipients. The invention also relates to process of preparation of such compositions.

Single unit oral dose pharmaceutical composition comprising levodopa, carbidopa and entacapone or salts thereof

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Latur, India

Manoj Mashalkar