Council of Scientific and Industrial Research

Manoj Kumar

Rajaram Bal

Ankur Bordoloi

Rajib Kumar Singha

Guruswamy Kumaraswamy

Neelima Dhingra

Tilak Raj Bhardwaj

Chandrashekar Pendem

Koneni Venkata Sashidhara

Bal Rajaram

Pendem Chandrashekar

Bordoloi Ankur

Konathala Laxmi Narayan Sivakumar

Reena Goyal

Subhasis Das

Ashootosh Vasant Ambade

Sivakumar Konathala Laxmi Narayan

Sudhir Kumar Sinha

Neraj Mehta

Necraj Mehta

Mayuresh Arvind Kulkarni

Jayanta Sarkar

Abdhesh Kumar

Neelam Naidu Botcha

Vemulapalli Venkata Durga Nagendra Prasad

Chandrasheka R Pendem

Saran Sandeep

Neeraj Mehta

The present invention discloses a method for preventing retraction of aqueous drops on a hydrophobic surface. The present invention also discloses a medical device coated with a hydrophilic coating comprising a substrate and a coating composition.

Method for preventing rectraction of aqueous drops and a medical device coated with hydrophilic coating

The present invention discloses reverse/inverse micellar discontinuous cubic phase (Fd3m phase) composition for controlled release of therapeutic drugs or biologically active component and to the process for preparation thereof.

Discontinuous reverse micellar composition in cubic FD3M phase for sustained release of therapeutic drugs

The present invention provides a process for the hydrogenation of the levulinic acid to &#x3b3;-valerolactone in a single step with a single Pt supported on hydrotalcite catalyst. The process provides conversion of &#x3b3;-valerolactone over Pt supported hydrotalcite catalyst at room temperature (25&#xb0; C.). The process provides a levulinic acid conversion of 34-100% with 20-50 bar hydrogen pressure to give &#x3b3;-valerolactone selectivity up to 99%.

Process for the production of &#x3b3;-valerolactone

The present invention provides a Ni nano-cluster supported on MgO&#x2014;CeO&#x2014;ZrOcatalyst and processes the production of the catalyst. Further, the present invention discloses use of Ni nano-cluster supported on MgO&#x2014;CeO&#x2014;ZrOcatalyst for the synthesis gas (a mixture of CO and H) by tri-reforming of methane. The process provides a direct single step selective vapor phase tri-reforming of methane to synthesis gas over NiO&#x2014;MgO&#x2014;CeO&#x2014;ZrOoxide catalyst between temperature range of 600&#xb0; C. to 800&#xb0; C. at atmospheric pressure. The process provides a methane conversion of 1-99% with Hto CO mole ratio of 1.6 to 2.3.

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The present invention provides a process and catalyst system for the production of synthesis gas (a mixture of CO and H) from greenhouse gases like methane and carbon di oxide. The process provide a single step selective reforming of methane with carbon dioxide to produce synthesis gas over Ce&#x2014;Ni&#x2014;MgAlOcatalyst prepared by using combination of two methods evaporation induced self-assembly and organic matrix combustion method. These suitably combined methods generate a unique catalyst system with very fine Ni nano clusters evenly dispersed in high surface area support. The process provides both Methane and carbon di oxide conversion more than 90% without any noticeable deactivation till 100 hours between temperature range of 500-800&#xb0; C. at atmospheric pressure.

The present invention relates to certain coumarin/chalcone compounds or a pharmaceutically acceptable salt thereof. The present invention particularly relates to the coumarin/chalcone compounds as anticancer agents useful for the treatment of cancer. The present invention also relates to the process of preparation of the said compounds. 

Coumarin-chalcones as anticancer agents

The present invention relates to steroidal esters of 17-oximino-5-androsten-3-ol, of compound of general formula (A) wherein R is selected from a group consisting of arylalkyl, aryl, substituted aryl. The ester derivatives are synthesized starting from Dehydroandrosterone acetate. The compounds were tested for their antiproliferative activity and 5&#x3b1;-reductase inhibitory activity in comparison to Finasteride. Decreased androgen level have been found in serum of animal treated with newly synthesized compounds. These compounds have also shown better cytotoxicity in comparison to reference drug Finasteride. Thus such compounds can be useful in treatment of androgen dependent disorder of prostate alone or by synergistic effect they can decrease the size of prostate due to their antiproliferative activity.

Steroidal esters of 17-oximino-5-androsten-3beta-ol

The present invention particularly relates to novel nitrate esters of paracetamol. The nitrate esters of paracetamol are prepared by reacting the paracetamol with dihaloalkyl compound and followed by reaction with silver nitrate to obtain the corresponding nitrate ester derivatives. The nitrate esters of paracetamol are useful as analgesic, anti-inflammatory agents.

Nitric oxide releasing derivatives of paracetamol

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Dehradun, India

Manoj Kumar