Fresenius Kabi Oncology Limited

Dabur Pharma Limited

Manoj Kumar Singh

Rama Mukherjee

Anand C Burman

Manu Jaggi

Dhiraj Khattar

Shobhit Kumar Singh

Mukesh Kumar

Deepak Prusthy

Pawan Kumar Gupta

Rajendran Praveen

Sanjoy Mullick

Anu T Singh

Subrata Sarkar

Jyan Shankar Mahanty

Vivek Kumar

Praveen Rajendran

Anand Vardhan

Mohammad Jamshed Ahmed Siddiqui

Shiv Kumar Agarwal

Nidhi Rani

Jayanta Chattopadhyay

Susanta Hazra

Moloy Mitra

Sanjay Kumar Srivastava

Hemant Kumar Jajoo

The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidne (VP), N-Isopropylactylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.

Biocompatible, non-biodegradable, non-toxic polymer useful for nanoparticle pharmaceutical compositions

The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidone (VP), N-Isopropylacrylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.

The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(&#x2550;CH)CHor CH(CH); Rtogether with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; Ror Rare hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or Rand Rare combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and Ris zero when Y is O, and Ris hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells. 

Betulinic acid derivatives

The invention provides two crystalline forms A and B of the skeletal muscle relaxant and anxiolytic agent, Metaxalone of formula (I), and a process for preparation thereof. The two crystalline forms A and B are bioavailable. The invention further provides pharmaceutical compositions comprising the two bioavailable crystalline forms, useful for the relief of discomforts associated with acute, painful musculoskeletal conditions. 

Metaxalone polymorphs

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Ghaziabad, India

Manoj Kumar Singh