Wayne State University

Manohar Ratnam

A pharmaceutical composition, comprising a compound having chemical structural formula I:

Methods and compositions relating to steroid hormone receptor-dependent proliferative disorders

Pharmaceutical compositions are provided according to aspects of the present disclosure which include a compound having chemical structural formula I: where Ris selected from the group consisting of: an alkyl group, a heteroalkyl group, an aryl group, a heteroaryl group, an alkenyl group, a heteroalkenyl group, an alkynyl group, a heteroalkynyl group, a cycloalkyl group, a hetercycloalkyl group, an alkylcycloalkyl group, a heteroalkyl cycloalkyl group, an aralkyl group, a heteroaralkyl group, an alkoxy group, a polar group, an ester and a charged group; a pharmaceutically acceptable hydrolysable, or enzymatically cleavable, prodrug form thereof; and/or a pharmaceutically acceptable salt thereof; where R′ is H or an alkoxy group; where both Rand R′ are OH, or where one or both OH groups is optionally modified as a pharmaceutically acceptable hydrolysable, or enzymatically cleavable, prodrug form thereof; and/or a deuterated form thereof; and/or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

There is a continuing need for methods and compositions relating to hormone-receptor-dependent cancers, including pharmaceutical compositions including one or more compounds having activity against steroid hormone-receptor-dependent cancer and methods of treatment of a steroid hormone-receptor-dependent cancer in a subject using said pharmaceutical compositions. ELK1 is a steroid hormone receptor tethering, protein that is implicated in hormone receptor dependent cancers. Compositions and methods according to aspects of the present invention inhibit the association of steroid hormone receptors with ELK1 providing activity against steroid hormone-receptor-dependent cancer. Such compositions are provided including any one or more of: chemical compound structures I, II, III, IV, V, VI, VII, one or more derivatives, and/or one or more: pharmaceutically acceptable esters and/or one or more pharmaceutically acceptable salts, of any thereof, wherein a pharmaceutically acceptable carrier may be included in the compositions.

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Toledo, OH, United States of America

Manohar Ratnam