Development Center for Biotechnology

Dcb-USA LLC

Mann-Yan Kuo

Ying-Shuan Eda Lee

Shih-Chieh Yen

Chu-Bin Liao

Shao-Zheng Peng

Yi-Ting Huang

Hung-Yi Hsu

Paonien Chen

Ming Shiang

Nan-Horng Lin

Li-Hsiu Lai

Li Jung Chen

Yann Yu Lu

Ping-Kuei Tsai

Chia-Wei Liu

Yann-Yu Lu

Seline Hsieh

Ju-Ying Yang

The present invention provides a compound of formula (1): wherein X, Y, Z, Z, R, R, A, B, p and q are as disclosed in the specification. A pharmaceutical composition and a method for modulating the Hedgehog pathway are also provided. The present invention rurthe r provides a process for preparing the compound.

Hetroarylamine compounds for modulating the hedgehog pathway and preparing method and uses thereof

A compound for treating a protein kinase-related disease or disorder having a structure of formula (I) wherein L is NRor O; R, R, R, R, R, Rand Rare defined herein. Compounds of formula (I) are useful for inhibition of protein kinases. Methods of using compounds of formula (I), stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Quinoxaline compounds, method for preparing the same and use thereof

The present invention relates to pyrimidine compounds of formula (I): which are useful in treating mTOR kinase- or PI3K kinase-related diseases.

Pyrimidine compounds as mTOR and PI3K inhibitors

A compound for treating a protein kinase-related disease or disorder having a structure of formula (I) wherein G is a heteroaryl, heterocyclic or alkyne; X is N or CH; Lis &#x2014;N(R)&#x2014;, &#x2014;O&#x2014;, &#x2014;C(S)&#x2014;, &#x2014;C(O)&#x2014;, or &#x2014;S&#x2014;; Lis &#x2014;N(R)&#x2014; or &#x2014;O&#x2014;; Rand Rare independently hydrogen, halogen, hydroxyl, amino, cyano, nitro, carboxy, C-Calkoxy, C-Calkoxy C-Calkoxy, N,N&#x2014;(C-Cdialkyl)amino C-Calkoxy, N&#x2014;(C-Calkyl)amino C-Calkoxy, C-Calkanoyl, C-Calkanoyloxy, N&#x2014;(C-Calkyl)amino, N,N&#x2014;(C-Cdialkyl)amino, C-Calkanoyl amino, or heterocyclyl, wherein C-Calkyl is optionally substituted with one or more substituents selected from fluorine and chlorine; R, Rand Rare independently hydrogen, fluorine or chlorine; Ris C-Calkyl or aryl, which is optionally substituted with one or more substituents selected from halogen, hydroxyl, amino, cyano, nitro; or Rand Rform a 5-6 membered cyclyl or heterocyclyl.

Quinazoline compounds, method for preparing the same and use thereof

Strains of streptomyces and relevant uses thereof

Strains of Streptomyces and relevant uses thereof

Growing community of inventors

Taipei, Taiwan

Mann-Yan Kuo