China Medical University

National Science Council

Mann-Jen Hour

Sheng-Chu Kuo

Yang-Chang Wu

Jai-Sing Yang

Li-Chen Chou

Tai-Lin Chen

Hong-Zin Lee

Po-Wu Gean

Kuo-Hsiung Lee

Li-Jiau Huang

Provided is a compound of the formula I or a pharmaceutically acceptable salt, solvate or stereoisomer thereof:  

2-aryl-4-quinazolinones and their pharmaceutical compositions

Two series of 6,7,2&prime;,3&prime;,4&prime;,5&prime;-substituted 2-phenyl-4-quinazolinones and 6,2&prime;,3&prime;,4&prime;,5&prime;-substituted 2,3-dihydro-2-phenyl-4-quinazolinones are synthesized and evaluated for cytotoxicity against a panel of human tumor cell lines, such as epidermoid carcinoma of the nasopharynx (KB), lung carcinoma (A-549), ileocecal carcinoma (HCT-8), breast cancer (MCF-7), melanoma (SKMEL-2), ovarian cancer (1A9), glioblastoma (U-87-MG), bone (HOS), P-gp-expressing epidermoid carcinoma of the nasopharynx (KB-VIN), and prostate cancer (PC3) cell lines, and some of the compounds are found potent. The present invention also synthesizes 2-phenyl-4-alkoxy-quinazoline compounds, wherein some of the compounds exhibit antiplatelet activity.

2-phenyl-4-quinazolinone compounds, 2-phenyl-4-alkoxy-quinazoline compounds and their pharmaceutical compositions

Growing community of inventors

Taichung, Taiwan

Mann-Jen Hour