Ipca Laboratories Limited

Elder Pharmaceuticals Ltd.

Manmohan Nimbalkar

Ashok Kumar

Satish Rajanikant Soudagar

Nalinakshya Balaram Panda

Abhay Atmaram Upare

Rajiv R Sakhardande

Rajesh Kumar Keshava Prasad Singh

Ashvini Kumar Nand Kishore Saxena

Vithal Kulkarni

Rajeshkumar Singh

Nilesh Wagh

Suhas M Nadkarni

Biphenyl compounds of Formula (I) and Formula (II), and their pharmaceutically acceptable salts or solvates or prodrugs, their pharmaceutical compositions, their use and process of preparation are provided. Compounds of Formula (I) and Formula (II) are disclosed to exhibit anti-inflammatory properties. 

Anti inflammatory compounds

Improved processes using primary, secondary and tertiary alcohols and with safer mode of introduction of the reagent and reaction conditions are described. Further, the process of manufacture of Losartan potassium by use of alkali metal salt such as Potassium carbonate is disclosed. A process for preparation of the polymorphic Form I of Losartan potassium is also disclosed herein.

Process for the synthesis of Losartan potassium

A process for the synthesis of Losartan Potassium by reacting Trityl Losartan in a primary alcohol with potassium tertiary alkoxide.

Losartan potassium synthesis

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Mumbai, India

Manmohan Nimbalkar