Techlab, Inc.

Manli Y Davis

David Maxwell Lyerly

Tracy Dale Wilkins

Krista A Williams

Jocelyn N Browning

Accurate and rapid differentiation of the outbreak strain ribotype 027 from other possible() strains, using stool samples, facilitates decision making for treatment options. Cell wall protein V (CwpV) contains a cell wall binding domain conserved amongstrains and a variable domain which is antigenically different amongstrains. In embodiments, antibodies against the 027-specific region in CwpV are used in diagnostic tests to detect ribotype 027 in culture or fecal samples.

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Accurate and fast detection of the presence of() disease is crucial for the proper treatment of patients withinfection. Present tests detecting the presence ofdisease are fast and cost effective, but are not very sensitive. Using an ELISA including Cell Wall Protein 84 (Cwp84) increases the sensitivity of the ELISA. Cwp84 may be used alone or in combination with other markers to support a diagnosis of-associated disease.

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Christiansburg, VA, United States of America

Manli Y Davis