Biocon Limited

Manjunath Hadavanahalli Shivarudraiah

Harish Iyer

Partha Hazra

Kedarnath Nanjund Sastry

Shrikumar Suryanarayan

Anand Khedkar

Nitesh Dave

Suma Sreenivas

Gautam Krishnan

Srikanth Gollarahosahalli Sathyanarayana

The present invention relates to the preparation of insulin compounds including their analogs or derivatives thereof from their corresponding precursor forms by a one step enzymatic reaction involving the combinatorial and concurrent use of optimal quantities of trypsin and carboxypeptidase B that work synergistically directing the reaction in a controlled manner to avoid production of random undesired byproducts. Particularly, the enzymatic conversion reactions of the instant invention offer advantages of reduction in the number operational steps, higher yield and purity of the desired end products.

Process for preparation of insulin compounds

The present invention discloses a process for making an insulin-oligomer conjugate as a one-pot reaction by conjugation of insulin-ester with an activated oligomer wherein simultaneous deblocking and conjugation is carried out.

Preparation of insulin conjugates

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Karnataka, India

Manjunath Hadavanahalli Shivarudraiah