Pfizer Corporation

Zoetis LLC

Manjinder Singh Lall

Timothy Allan Johnson

Joseph Scott Warmus

Matthew Frank Brown

Mark Edward Flanagan

Clarke Bentley Taylor

Steven J Brickner

Edmund Lee Ellsworth

Sean Timothy Murphy

Denton Wade Hoyer

Debra Ann Sherry

Charles Francis Donovan

Peter Laurence Toogood

Mark E Schnute

Chris Limberakis

Michael P Curtis

Brian Stephen Gerstenberger

Seungil Han

Mark J Mitton-Fry

Wenhua Jiao

Timothy Allen Johnson

Mark Stephen Plummer

Hud Lawrence Risley

Chris Lim-Berakis

Veerabahu Shanmugasundaram

Ricardo Lira

Steven Joseph Brickner

Jeremy T Starr

A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein Rand Rare each independently hydrogen or hydroxy; wherein Rand Rare not both hydroxy. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations thereof with other therapeutic agents.

Aminopyrimidinyl derivatives

The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, thereof, wherein: and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates, thereof, wherein A, B, L-L, A, B, R-R, and m are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and their use in treating a bacterial infection.

Hydroxamic acid derivatives useful as antibacterial agents

Described herein are antibacterial compounds of formula I, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical composition.

Tricyclic tetrahydroquinoline antibacterial agents

The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, thereof, wherein: G is a group of formula (II); and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates, thereof, wherein A, B. L-LA, B, R-Rand m are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and their use in treating a bacterial infection.

The invention relates to compounds of formula (I): wherein R, R, R, R, R, and Ras defined herein. The invention also relates to pharmaceutical compositions and methods of treating bacterial infections using compounds of formula (I).

Monocarbams

Growing community of inventors

East Lyme, CT, United States of America

Manjinder Singh Lall