Bayer Oy

Manja Ahola

Jyrki Pihlaja

Heikki Lyytikäinen

Harri Jukarainen

Ulrike Fuhrmann

Bernhard Lindenthal

Ina Gröticke

Bernd Duesterberg

Satu Kleemola

Tero Parkatti

Tuula Valo

Antti Keinänen

Risto Hakala

Piia Hara

Henriikka Korolainen

The present invention relates to a method for modifying release of a therapeutically active agent from an elastomeric matrix, comprising providing a core comprising an elastomeric matrix and a therapeutically active agent; dipping the core to a coating solution of an elastomer, wherein the elastomer comprises 20-35 wt-% of a filler, calculated from the total amount of filler and elastomer; curing the dipped core to provide a coated core. In this method the dipping is provided as a continuous process by pulling the core through the coating solution, using a pulling speed suitable for providing a coating thickness of &#x3b4;-IOOthe filler is selected from silica, titanium dioxide, barium sulphate, carbon and mixtures thereof; the elastomer comprised in the core and the elastomer comprised in the coating solution are independently selected from poly(dimethyl) siloxanes, polyethylene vinyl acetates (EVAs), polyurethanes (PUs), polyhydroxyethyl methacrylates (PHEMAs) and polymethyl methacrylates (PMMAs).

Method for modifying release of a therapeutically active agent from an elastomeric matrix

The invention relates to a method for contraception and for reducing menstrual problems and inducing amenorrhea, wherein an intrauterine delivery device is used for the controlled release of a combination of progestogen or a drug having a progestogenic activity and at least one therapeutically active substance capable of preventing or suppressing abnormal and/or irregular endometrial bleeding over a prolonged period of time.

Intrauterine delivery system for contraception

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Plikklo, Finland

Manja Ahola