University of Louisville Research Foundation

Manikandan Ravi

Susan Jill Harkema

Claudia A Angeli

Douglas J Jackson

John F Naber

Robert S Keynton

Yangsheng Chen

Thomas Roussel

Yangshen Chen

Charles S Hubscher

Saliya Kirigeeganage

Charles Hubscher

Disclosed herein are devices and methods used with neurostimulation therapy for spinal cord injury. More particularly, embodiments of the present invention relate to a sync pulse detector and methods for synchronizing signals from an implanted neurostimulator with measured physiological responses and other data.

Sync pulse detector

Patients with spinal cord injuries have benefited from neurostimulation therapy comprising delivery of electrical stimulation to enable or excite neurological responses using an implantable neurostimulator having an electrode array. Dangerous levels of charge are avoided while providing multiple, simultaneous stimulation waveforms by inducing a short in an electrode when a monitored value reaches or exceeds a predetermined threshold.

Methods for neurostimulator pulse overlap control

Disclosed herein are methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for providing multiple independent, simultaneous waveforms in neurostimulation therapy while minimizing or substantially eliminating undesirable interactions between the waveforms.

Methods for providing optimized neurostimulation

Embodiments of the present invention relate to methods for applying epidural electrical stimulation to improve motor function or physiological responses in paralyzed individuals. More particularly, the present invention relates to methods for creating and applying specific configurations of epidural stimulation to assist or cause a patient to perform a complex motor function or to mitigate one or more secondary consequences of paralysis including, but not limited to, cardiovascular, respiratory, bladder, temperature and sexual dysfunction.

Methods for applying epidural electrical stimulation

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Louisville, KY, United States of America

Manikandan Ravi