Arizona State University

Manikandadas Mathilakathu Madathil

Sidney M Hecht

Rakesh Paul

Chandrabali Bhattacharya

Michael James Rishel

Omar Khdour

Trevor Bozeman

Zhiqiang Yu

Chenhong Tang

This invention relates to compounds comprising a saccharide conjugated to an imaging agent or a reporter group, compositions comprising them and methods of using them. Specifically BLM-disaccharide and BLM-monosaccharide conjugates containing different linker groups and an imaging agent or a reporter group are provided for the targeting and imaging of tumors.

Saccharide conjugates

The invention provides a compound of formula (I): [insert formula (I)] wherein X, Y, and R-Rhave any of the values defined in the specification, and salts thereof, as well as compositions comprising the compounds or salts. The compounds are useful for treating diseases associated with impaired mitochondrial function in an animal. 

Multifunctional radical quenchers

The present disclosure relates to sugar-linker-drug conjugates, of the formula [A-B-]n-L-D, wherein A is a saccharide; B is a spacer, n is an integer selected from 1 to 3; L is a linker group and D is a drug having a chemically reactive functional group selected from the group consisting of a primary or secondary amine, hydroxyl, sulfhydryl, carboxyl, aldehyde and ketone. Pharmaceutical compositions comprising the conjugates and methods of using them are also provided.

Sugar-linker-drug conjugates

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Tempe, AZ, United States of America

Manikandadas Mathilakathu Madathil