Indoco Remedies Limited

Mangesh Narayan Rajadhyaksha

Aditi Milind Panandikar

Ranjeet Nair

Sandip Kacharu Deshmukh

Nilesh Balkrishna Shrigadi

Somnath Ambadas Khabale

Panandikar Aditi Milind Milind

The present invention discloses novel process for the preparation of (2R)-2-acetamido-N- benzyl-3-methoxypropanamide of Formula I involving novel intermediates of Formula-XIX and Formula-XX. 

Process for preparation of lacosamide and some N-benzyl-propanamide intermediate derivatives

Disclosed herein is an improved process for the preparation of 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol of Formula-I and its pharmaceutically acceptable salt which comprises the reaction of (S)-1-(dimethylamino)-2-methylpentan-3-one of formula VIII with 3-bromo anisole of formula II under Grignard conditions to get the compound (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3-ol of formula V followed by activation of the &#x2014;OH group of the formula V to convert into sulfonate esters of formula IX, which are on reductive deoxygenation to yield (2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpentan-1-amine of formula VII and demethylation of formula VII to obtain the compound 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol of Formula-1.

Process for the preparation of tapentadol

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Mumbai, India

Mangesh Narayan Rajadhyaksha