Studiengesellschaft Kohle Mbh

Other

Brain Corporation

Manfred T Reetz

Gunther Lohmer

Gerlinde Mehler

Renate Lohmer

Albin Zonta

Jorg Simpelkamp

Wolfgang Helbig

Stefan Andreas Quaiser

Andreas Meiswinkel

Marco Lopez

Christian Psiorz

Karl-Erich Jäger

Hanno Brummer

Klaus Kühling

G&uuml;nter Dumpich

Heinz Mehlhorn

Martin Winter

Jens Lohau

Felipe Emilio Zilly Claude

Michael Heinrich Becker

Siegfried Waldvogel

Detlef St&ouml;ckigt

Heinz-Werner Klein

Thomas Knauf

Thorsten Sell

Andreas Gosberg

Marc Willuhn

Elke Westermann

A method is described for the oxidation of organic compounds in which the organic compound that is to be oxidized is brought to reaction in an aqueous solution in the presence of cytochrome P 450, and wherein perfluorinated organic compound is added to the aqueous reaction mixture as activator.

Method for the oxidation of organic compounds

A process is described for preparing aromatic and heteroaromatic amines of the general formula (I) Ar&#x2014;NRR, in which an aromatic compound with the general formula (II) Ar&#x2014;X is reacted in the presence of a catalyst with an amine of the general formula (III) H&#x2014;NRRand a base, wherein the catalyst is selected from transition metal complexes having one or more ligands with the general formula (IV).

Process for preparing aromatic and heteroaromatic amines

The invention relates to certain chiral transition metal catalysts, to the metal of which at least two structurally different monophosphorus ligands are bonded, at least one of said monophosphorus ligands being chiral. Said chiral transition metal catalysts are suitable as catalysts for use in asymmetric transition metal-catalyzed reactions, providing better enantioselectivities than in cases where only one structurally defined ligand is used.

Mixtures of chiral monophosphorus compounds used as ligand systems for asymmetric transition metal catalysis

Certain chiral monophosphites and their monothio derivatives are suitable as ligands in the asymmetrical transition-metal-catalyzed hydrogenation, hydroborination and hydrocyanation of prochiral olefins, ketones and imines.

Chiral monophosphites as ligands for asymetrical synthesis

The invention relates to heterogeneous catalysts which are particularly easy to produce. Said heterogeneous catalysts are generated by immobilizing preformed monometallic or multimetallic metal oxide particles in situ on an oxidic or non-oxidic carrier, wherefore metal oxide colloids which are stabilized by hydroxide ions and immobilized on carriers contained in the suspension are generated from conventional, water-soluble metal salts by means of hydrolysis and condensation. The inventive method makes it possible to produce fuel cell catalysts, for example.

Method for in situ immobilization of water-soluble nanodispersed metal oxide colloids

The present invention relates to compounds having antibiotic activity which are obtained from body fluids of mollusks, namely of certain West-African snails, to therapeutic drugs comprising these compounds, and to the use thereof for the preparation of a therapeutic drug for controlling infectious pathogens in humans and animals.

Compounds exhibiting an antibiotic activity

The present invention relates to a method for determining the enantioselectivity of kinetic resolution processes and of asymmetrically proceeding reactions of prochiral compounds bearing enantiotopic groups by using isotope-labeled substrates so that the reaction products can be quantitatively determined with an isotope-specific detection system, e.g., an ESI mass spectrometer. In connection with automated sample charging, the method can be employed for high throughput screening. The relevant enantioselective conversions can be induced by chiral homogeneous or heterogeneous catalysts, biocatalysts or stoichiometric amounts of optically active agents.

High-throughput-screening method for determining enantioselectivity

The present invention relates to novel chiral 1,1&prime;-ferrocenylene diphosphonites and the synthesis thereof, in addition to complexes of said compounds with metals from groups VIIb, VIIIb and Ib of the Periodic Table and to the use thereof for enantioselective hydrogenation of olefins, ketones and imines, or enantioselective hydroboration and 1,4-addition to activated olefins.

Ferrocene-based diphosphonites for asymmetrical catalysis

Olefins containing aromatic substituents are synthesized without the addition of phosphonium salts or phosphanes with the aid of a Pd compound as a catalyst in the presence of nitrogen-containing additives such as N,N-dimethylglycine and a base.

Method for producing olefins

A process for the synthesis of olefins having aromatic substituents is described in which olefins are reacted with aryl halides in the presence of catalysts consisting of palladium compounds and tetraaryl phosphonium salts.

Process for the preparation of an olefin-substituted aromatic or heteroaromatic compound

A lithographic method for the generation of nanostructures on surfaces, characterized in that either stabilized nanometer-sized transition metal clusters or colloids of metals of groups 4, 5, 6, 7, 8, 9, 10, 11 or 12 of the Periodic Table, their stabilized metal oxide or metal sulfide analogues, polynuclear metal carbonyl clusters having stoichiometrically defined compositions, or polynuclear metal clusters having stoichiometrically defined compositions or having bridges consisting of main group elements, respectively in the form of a solution, are coated on a surface as a film which is imagewise exposed with an electron beam, wherein defined structures in the nanometer range are generated on the surface after washing off the unexposed portions of the film, optionally followed by annealing.

Lithographical process for production of nanostructures on surfaces

Solvent-stabilized transition metal colloids are prepared either electrochemically by cathodically reducing metal salts in the presence of polar stabilizing solvents to form metal colloids, or the transition metal salts are reduced in polar solvents using an alcohol at elevated temperatures.

Process for preparing solvent-stabilized metal colloids and substrate-immobilized metal clusters

Olefin hydroformylation process in a two-phase system

Lipases are immobilized by entrapment in silicon-containing matrices obtained by hydrolysis of alkoxy-silicon compounds in the presence of a catalyst and additives such as proteins, polyhydroxy compounds, insoluble organic polymers and/or insoluble inorganic compounds. The entrapped lipase may be used for treatment of digestive insufficiency in a patient caused by pancreatic disease or cystic fibrosis.

Growing community of inventors

Mülheim an der Ruhr, Germany

Manfred T Reetz