Sanofi Pasteur Sa

Glatt Gmbh

Glatt Process Technology Gmbh

Manfred Struschka

Bernhard Luy

Matthias Plitzko

Thomas Gebhard

Roland Kaiser

Christian Zerillo

Jochen A Dressler

Matthias Tondar

Winfried Thomann

A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer for the bulkware production of freeze-dried particles under closed conditions, the freeze-dryer comprising a rotary drum for receiving the frozen particles, and a stationary vacuum chamber housing the rotary drum, wherein for the production of the particles under closed conditions the vacuum chamber is adapted for closed operation during processing of the particles; the drum is in open communication with the vacuum chamber; and at least one transfer section is provided for a product transfer between a separate device of the process line and the freeze-dryer, the freeze-dryer and the transfer section being separately adapted for closed operation, wherein the transfer section comprises a temperature-controllable inner wall surface.

Process line for the production of freeze-dried particles

A heating device () for heating particles to be freeze-dried in a rotary drum () of a freeze-dryer () is provided, the device comprising at least one radiation emitter () for applying radiation heat to the particles, and a tube-shaped separator () for separating the particles from the at least one emitter (), The separator () being integrally closed at one end and separating an emitter volume () encompassing the at least one emitter () from a drum process volume () inside the drum (), wherein the heating device () protrudes into the drum process volume () such that said integrally closed end of the separator () is arranged inside the drum () as a free end.

Heating device for rotary drum freeze-dryer

The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamber.

Liquid feeding device for the generation of droplets

A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer () for the bulkware production of freeze-dried particles under closed conditions, the freeze-dryer () comprising a rotary drum () for receiving the frozen particles, and a stationary vacuum chamber () housing the rotary drum (), wherein for the production of the particles under closed conditions the vacuum chamber () is adapted for closed operation during processing of the particles. The drum () is in open communication with the vacuum chamber () and at least one transfer section () is provided for a product transfer between a separate device of the process line and the freeze-dryer (), the freeze-dryer () and the transfer section () being separately adapted for closed operation, wherein the transfer section () comprises a temperature-controllable inner wall surface.

A heating device () for heating particles to be freeze-dried in a rotary drum () of a freeze-dryer () is provided, the device comprising at least one radiation emitter () for applying radiation heat to the particles, and a tube-shaped separator () for separating the particles from the at least one emitter (). The separator () being integrally closed at one end and separating an emitter volume () encompassing the at least one emitter () from a drum process volume () inside the drum (), wherein the heating device () protrudes into the drum process volume () such that said integrally closed end of the separator () is arranged inside the drum () as a free end.

A process line () for the production of freeze-dried particles under closed conditions is provided, the process line comprising at least the following separate devices: a spray chamber () for droplet generation and freeze congealing of the liquid droplets to form particles, and a bulk freeze-dryer () for freeze drying the particles, wherein a transfer section () is provided for a product transfer from the spray chamber () to the freeze-dryer (), for the production of the particles under end-to-end closed conditions each of the devices () and of the transfer section () is separately adapted for closed operation, and the spray chamber () is adapted for separation of the liquid droplets from any cooling circuit.

A process line () for the production of freeze-dried particles under closed conditions comprising at least a spray chamber () for droplet generation and freeze congealing of the liquid droplets to form particles and a bulk freeze-dryer () for freeze drying the particles, the freeze-dryer () comprising a rotary drum for receiving the particles. Further, a transfer section () is provided for a product transfer from the spray chamber () to the freeze-dryer (). For the production of the particles under end-to-end closed conditions each of the devices () and of the transfer section () is separately adapted for operation preserving sterility of the product to be freeze-dried and/or containment.

A rotary drum () for use within a vacuum chamber () in a vacuum freeze-dryer () for the bulkware production of freeze-dried particles is provided. The drum () is in open communication with the vacuum chamber () and comprises a main section () terminated by a front plate () and a rear plate (), the rear plate () is adapted for connection with a rotary supporting shaft () for rotary support of the drum (), and the rear plate () is permeable for sublimation vapor from freeze-drying the particles.

Rotary drum for use in a vacuum freeze-dryer

The invention concerns a spray nozzle for a fluidized bed device, said nozzle comprising a central liquid outlet () for a liquid coating agent and an annular air outlet () for conveying spraying air coaxially. An enclosing body () having a central recess () is maintained in a wall of the box of the fluidized bed device. Said enclosing body () is connected to a spraying air source through an air duct () and an axially mobile nozzle head () is centrally mounted inside said enclosing body (). Said nozzle head () is connected to a liquid coating agent source through a liquid duct (), said liquid duct () having a flexible tubular section () and being centrally guided inside the air duct ().

Spray nozzle for fluidized bed device

A process for measuring, monitoring and/or controlling directed product movements of fluidized products in process systems () selected from fluidized bed and spouted bed systems during a spraying process for coating and/or granulation, which includes, with the aid of one or more microwave sensor devices (), injecting microwave radiation without contact into one or more product streams, receiving the microwave radiation reflected by the particles of the particular product stream and, on the basis of the microwave radiation received, forming and transmitting a measurement signal for the characterization of the product stream, the corresponding use of microwave sensor devices () and correspondingly equipped apparatus ().

Measurement, monitoring and control of directed product movements in a Wurster-arrangement and suitable systems

A fluidized bed reactor for granulating and coating particles in very small amounts having an essentially conical product container, a filter housing with filters inserted above the product container, and a lower housing below the conical product container having a process air supply. The product container has a sieve bottom in the center of which is a height-adjustable two-component nozzle. At least one guide element associated with the sieve bottom directs at least part of the process air to the two-component nozzle in a radial manner.

Growing community of inventors

Auggen, Germany

Manfred Struschka