Hoechst Aktiengesellschaft

Hoeschst Aktiengesellschaft

Manfred Rosner

Wolfgang Raether

Reinhard Kirsch

Irvin Winkler

Heinz Loewe

Gunther J Riess

Jorg-Peter Kleim

Dieter Duwel

Christoph Meichsner

Uta-Maria Billhardt-Troughton

Hans-Jochen Lang

Andreas W Herling

Josef Urbanietz

Robert Rippel

Heinz Mehlhorn

Gunter Schmahl

Rudolf Bender

Weidmann, Klaus

Bernd Rosenstock

Horst Taraschewski

Substituted quinoline derivatives with antiviral action

Compounds of the formula I, ##STR1## and also their tautomeric forms of the formula Ia, ##STR2## in which the substituents R.sup.1 to R.sup.6 and X have said meanings, exhibit antiviral activity.

Substituted quinoline derivatives, a process for their preparation, and

Disclosed are quinoxalinone compounds of the formula I or Ia ##STR1## and physiologically tolerated salts and prodrugs thereof, in which n=zero, one or two;

Quinoxalines, a process for their preparation and their use

Compounds of the formula I ##STR1## and their tautomeric form of the formula Ia ##STR2## in which the substituents R.sup.1 to R.sup.5 and V, W, Y and Z have the stated meanings, display an effect against viruses.

Azaquinoxalines and their use

A method of using certain triazine-dione compounds for the control of endo- and ectoparasites of fish and/or insects. The compounds may be combined with aids to form an agent for controlling the endo- or ectoparasites.

Agents directed against parasites of fishes and insects

Thienoimidazole-toluidines of the formula I ##STR1## in which A represents ##STR2## T denotes --S--, --SO-- or --SO.sub.2 --, and R.sup.1 to R.sup.9 have the meanings stated in the description, and a process for their preparation, pharmaceutical compositions containing them, and their use as inhibitors of gastric acid secretion, are described.

Substituted thienoimidazole-toluidine derivatives as inhibitors of

Compounds of the formula I ##STR1## with n=1-3, R=H, Hal, CF.sub.3, alkyl, cycloalkyl, alkyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, benzylsulfinyl, benzylsulfonyl, nitro, cyano, amino, alkylamino, dialkylamino, piperidino, morpholino, pyrrolidinyl, 4-methyl-1-piperazinyl, acylamino or substituted phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, benzoyl, benzoylamino or anilino, with R.sup.2 =H, alkyl, cycloalkyl, optionally substituted benzyl, alkanoyl or benzoyl and R.sup.3 =H, alkyl, cycloalkyl or optionally substituted benzyl, at least R.sup.2 or R.sup.3 not being H, are obtained by alkylation or acylation of a compound II ##STR2## in which R.sup.1 is as defined above, with compounds R.sup.3 X (X=leaving group) or R.sup.2 Y (Y=leaving group), R.sup.2 and R.sup.3 being defined as indicated. Compounds I are coccidiostatics.

2-phenylhexahydro-1,2,4-triazine-3-,5-diones

Substituted 2-phenyl-hexahydro-1,2,4-triazine-3,5-diones of the formula ##STR1## in which n is one, two or three and the individual substituents R are independently of one another (a) hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, alkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl each having 1 to 6 carbon atoms in the alkyl moiety, nitro, cyano, amino, alkylamino or dialkylamino each having 1 to 12 carbon atoms in the alkyl moiety, piperidino, morpholino, thiomorpholino, 1-pyrrolidinyl, 4-methyl-1-piperazinyl or acylamino having 1 to 6 carbon atoms in the acyl moiety, or (b) a phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl, benzoyl, benzoylamino or aniline radical which is in each case R.sub.(a) -substituted, and the alkali metal salts, alkaline earth metal salts or ammonium salts thereof, a process for their preparation, their use, veterinary drugs and a process for controlling protozoal diseases.

2-phenyl-hexahydro-1,2,4-triazine-3,5-diones

New phenylsulfonyloxybenzimidazolecarbamates of the formula ##STR1## are described, as are processes for their preparation. The new compounds have anthelmintic activity, including, in particular, against liver flukes.

Substituted phenylsulfonyloxybenzimidazolecarbamates and anthelmintic

New benzenesulfonic esters of the formula I ##STR1## and a process for their preparation are described. The new compounds are active against helminths and can thus be used as agents to counter worms in humans and animals.

Substituted benzenesulfonic esters and their use as medicaments for

Novel substituted 2-phenyl-1,2,4-triazine-3,5-(2H,4H)-diones are described as well as a process for their manufacture. The novel compounds may be used as chemotherapeutics, especially as coccidiostatic agents.

Substituted 2-phenyl-1,2,4-triazine-3,5(2H,4H)-diones, and

Substituted bis-benzimidazolyl compounds of the formula ##STR1## are disclosed, wherein A is thiophenediyl, furanediyl, phenylene, or phenoxyphenylene, and R.sup.1 is ##STR2## where R.sup.2 -R.sup.10 are independently hydrogen, alkyl, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, or phenyl, or any two of R.sup.2 -R.sup.10 taken together are C.sub.2 -C.sub.4 alkylene, as are methods of making the compounds, which are useful as chemotherapeutic agents in the treatment of protozoal and viral diseases.

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Eppstein, Germany

Manfred Rosner