A. Nattermann & Cie Gmbh

Nattermann & Cie Gmbh

Manfred Probst

Hans-Heiner Lautenschlager

Hans Betzing

Brigitte Stoll

Johannes Winkelmann

Gerd Hilboll

Ferdinand Wirtz-Peitz

The present invention refers to N-Benzoyl-.omega.-anilinoalkane carboxylic acids, their esters and salts of the general formula ##STR1##

N-Benzoyl-.omega.-anilino alkane carboxylic acids and salts and esters

The present invention refers to new .omega.-(2-oxo-benzazolinyl)-alkanoic acids as well as salts and esters thereof having the general formula I ##STR1## and having antiinflammatory, analgesic and antithrombotic activity.

.omega.-(2-Oxo-benzazolinyl)-alkanoic acid derivatives

The present invention is directed to a new rosmarinic acid-phospholipide-complex product containing rosmarinic acid and the phospholipide in a molar ratio of 1:2. The invention is further directed to a process for producing the same and to pharmaceutical preparations containing the same.

Rosmarinic acid-phospholipide-complex

The present invention refers to new 5-(N-Alkyl-N-acyl-amino)-thiophen-2-carboxylic acid derivatives having the general formula I ##STR1##

5-(N-Alkyl-N-acyl-amino)-thiophen-2-carboxylic acid derivatives

The present invention refers to N-substituted .omega.-(2-oxo-4-imidazolin-1-yl) alcanoic acids as well as salts and esters thereof having the general formula I ##STR1## The compounds are useful, for example, as antiallergics, antiasthmatics, etc.

N-Substituted .omega.-(2-oxo-4-imidazolin-1-yl) alcanoic acids and salts

The invention provides novel .omega.-(5-alkenylthien-2-yl)alkanecarboxylic acids and their functional derivatives having the formula ##STR1## wherein n is an integer from 1 to 9, inclusive; R.sup.1 is H and R.sup.2 is --OH, or R.sup.1 and R.sup.2 together with the wavy lines represent a keto group; and R.sup.3 is H, C.sub.1 -C.sub.6 straight or branched-chain saturated hydrocarbon, or a pharmaceutically acceptable alkali cation. The 3-oxoalkenyl-substituted compounds of formula (I) are prepared by a Wittig-Horner reaction using a 2-oxoheptylphosphonic acid dialkyl ester and an aldehyde of the formula ##STR2## as starting materials, while the 3-hydroxyalkenyl-substituted compounds are obtained by reduction of the corresponding 3-oxoalkenyl compounds. The esters of formula (I) can also be readily converted to the corresponding acids and salts of formula (I). The compounds of the invention have valuable anti-inflammatory, antipyretic and anti-arteriosclerotic properties, yet have low toxicity and do not irritate the gastric mucosa.

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Frechen, Germany

Manfred Probst