Bayer Aktiengesellschaft

Miles Inc.

Bayer Akteingesellschaft

Manfred Plempel

Karl H Buchel

Wolfgang Kramer

Erik Regel

Werner Meiser

Ingo Haller

Klaus Schaller

Wilfried Draber

Graham Holmwood

Hans-Ludwig Elbe

Franz Kunisch

Richard F Hector

Heinrich F Moeschler

Jurgen Wenzelburger

Joachim Mittendorf

Wilhelm Brandes

Karl G Metzger

Stefan Dutzmann

Dieter Arlt

Heinz-Wilhelm Dehne

Rainer Endermann

Udo Kraatz

Klaus-Dieter Bremm

Peter Babczinski

Klaus Stroech

Michael Matzke

Hans-Christian Militzer

Paul-Ernst Frohberger

Dieter Berg

Wolf Reiser

Arnold Paessens

Miklos Von Bittera

Carl Metzger

Gert Streissle

Karl H B/u/ Chel

Manfred Jautelat

Jorg Stetter

Hans-Joachim Zeiler

Thomas Himmler

Klaus Sasse

Ulrich Reinehr

Gerhard Jager

Horst Boshagen

Klaus Bockmann

Wolfgang Springer

Wolfgang Gau

Monika Frie

Georg-Wilhelm Ludwig

Manfred Bucheler

Burkhard Fugmann

Antonius Lobberding

Walter Radt

Andreas Schulze

Wolfgang Kr/a/ Mer

Susanne Backens-Hammerschmidt

Ludwig Elbe

Hans-Jurgen Ploschke

The invention relates to cyclopentane- and -pentene-.beta.-amino acids, processes for their preparation and their use as medicaments, and to prevent contamination of materials such as wood and leather.

Method of preserving materials using

New Cyclopentane- or cyclopentene-beta-aminoacid derivatives and their isomers, acid additional salts and metal salt complexes have strong antimicrobial and broad-spectrum antimycotic acitivity. As antimycotics they are especially active against dermatophyte, and biphasic fungi. The new compounds are also low toxicity antibacterial agents, effective against Gram positive bacteria, including antibiotic-resistant strains. The new Cyclopentane- or cyclopentene-beta-aminoacid derivatives are useful in human or veterinary medicine for combating dermatomycosis or systemic mycosis or local or systemic bacterial infections. In addition, the new compounds can also be used as preservatives, especially for water, foods, or organic materials such as polymers, lubricants, paints, fibers, leather, paper or wood.

Cyclopentane- and -pentene-.beta.-amino acids

The invention relates to cyclopentane- and -pentene-.beta.-amino acids, processes for their preparation and their use as medicaments.

Polynucleotide and oligonucleotide probes are described for the diagnostic investigation of mycoses which are caused by Candida albicans. These gene probes are complementary to parts of the genome of C. albicans and are suitable for identifying C. albicans nucleic acids in any sample material, even that which has been amplified. They do not hybridise with nucleic acids from other fungi, bacteria, animals or plants. Processes are described for the diagnosis of C. albicans in clinical samples as well.

Specific gene probes and processes for the diagnostic investigation of

There are described new 2-cyclohexan-1-yl-amine derivatives of formula (I) ##STR1## in which A, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meaning given in the description, and processes for their preparation. The compounds of the formula (I) are used as anti-microbial agents.

Antimicrobial agents which are substituted 2-cyclohexan-1-yl-amine

Nikkomycin compounds have been found to be orally or parenterally effective as anti-fungals in animals. They may be used alone or, preferably, in combination with azole antimycotics for a synergistic anti-fungal effect.

Antimycotic compositions of nikkomycin compounds and azole antimycotics

The invention relates to the use of substituted tetrahydrothiophenes, some of which are known, as medicaments, in particular as antimycotic agents, to new active substances and to processes for their preparation.

Use of substituted tetrahydrothiophenes, some of which are known, as

The present invention relates to the use of known substituted 2-cyclohexene derivatives in the control of diseases, in particular bacterial infections and mycoses.

Medicaments containing substituted 2-cyclohexene derivatives and their

Novel antimycotic carbonyl- and amino-substituted tetrahydrofurans of the formula ##STR1## in which one of A and B is an oxygen atom and the other -CHR.sup.5,

Antimycotic carbonyl- and amino-substituted tetrahydrofurans

New compounds of the formula (I) ##STR1## in which R.sup.1 -R.sup.6 have the meanings given in the description, their preparation and use in plant protection, the protection of materials and in the field of human and veterinary medicine. Formula (I) gives a definition of the compounds which can be prepared by analogous processes, for example from suitable benzothiophene derivatives by oxidation.

Benzothiophene-2-carboxamide S,S-dioxides and use

There are described new 2-cyclohexan-1-yl-amine derivatives of formula (I) ##STR1## in which A, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meaning given in the description, and processes for their preparation. The compounds of the formula (I) are used as antimicrobial agents.

Compounds useful as antimicrobial agents

The nikkomycin compound possessing antimycotic activity and having the following structure: ##STR1##

Nikkomycin derivatives

Antimycotically active azolyl-cyclopropyl-azolylmethylcarbinol compound of the formula ##STR1## in which R.sup.1 - represents hydrogen, or alkyl which is optionally substituted by optionally substituted aryl or

Substituted bisazoles and their use as medicaments

Growing community of inventors

Haan, Germany

Manfred Plempel