Febit Holding Gmbh

Febit Biotech Gmbh

Synthetic Genomics, Inc.

Manfred Müller

Peer Friedrich Stähler

Cord Fredrich Stähler

Hans Lindner

Fritz Stähler

Ralf Mauritz

Cord F Stähler

Peer F Stähler

The invention relates to a method for producing polymers, in particular synthetic nucleic acid double strands of optional sequence, comprising the steps:

Method for producing polymers

The invention relates to a method for producing polymers, in particular synthetic nucleic acid double strands of optional sequence, comprising the steps: (a) providing a support having a surface area which contains a plurality of individual reaction areas, (b) location-resolved synthesizing nucleic acid fragments each having different base sequences in several of the individual reaction areas, and (c) detaching the nucleic acid fragments from individual reaction areas.

The present invention relates to arrays of biochemical and/or biofunctional elements such as nucleic acids (oligonucleotides, for example) or other biomolecules on a carrier surface and methods of producing such arrays using photoactivation of predetermined areas for synthesis using an illumination matrix that is computer-controlled to generate an exposure pattern. This exposure pattern can be adjusted and monitored by computer using a light sensor matrix, for example a CCD matrix, to allow precise, controlled illumination of specific regions and therefore attachment of array building blocks to those specific regions. The methods and compositions of the invention permit spatially resolved photochemical synthesis of polymer probes on a carrier.

Method and device for producing biochemical reaction supporting materials

The present invention relates to a microfluid reaction carrier intended for the purely fluid or light-controlled synthesis or analysis of oligomers or polymers. The reaction carrier comprises a structure of flow channels for the fluids, while supply channels and discharge channels parallel to the latter form an angle relative to the plane of the structure of the flow channels (reaction areas).

Microfluid reaction carrier having three flow levels and a transparent protective layer

A method for producing a support for determining analytes. The method comprises the steps of (a) providing a support comprising at least one channel, comprising a conduit having an intake and an outlet for passing fluid from the intake to the outlet, in the support body, (b) passing liquid with building blocks for synthesizing polymeric receptors through the channel or channels of the support body, (c) site- and/or time-specifically immobilizing the receptor building blocks in each case on predetermined positions in the channel or channels by illumination and (d) repeating steps (b) and (c) until the required receptors have been synthesized in each case on the predetermined positions.

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Munich, Germany

Manfred Müller