Mikrogen Molekularbiologische Entwicklungs - Gmbh

Roche Diagnostics Gmbh

Other

Mikrogen Molekularbiologische Entwickslung-gmbh

Mikrogen Molekularbiogische Entwicklungs - Gmbh

Manfred Motz

Erwin Soutschek

Renate Fuchs

Bettina Wilske

Vera Preac-Mursic

Erwin Soutscheck

Christoph Seidel

Urban Schmitt

Barbara Upmeier

Ursula-Henrike Wienhues

Michael Wiedmann

Georg Bauer

Hans Joachim Wolf

Michael Roggendorf

Udo Reischl

Klaus Fuchs

The invention relates to single domain VHH fragments which specifically bind to and inhibit superoxide dismutase and/or bind to and inhibit catalase and/or bind to and inhibit superoxide dismutase and catalase, in particular for the use in the therapy of tumor diseases.

Antigen-binding constructs that bind to and inhibit catalase and/or superoxide dismutase as well as pharmaceutical compositions containing them for tumor therapy

In the area of virus diagnosis, in particular Epstein-Barr virus (EBV) diagnosis, methods for the detection of EBV and agents suitable for this purpose are provided, including peptides which are derived from p18-VCA and permit discrimination between acute and past EBV infection.

Peptides derived from capsid antigens of the Epstein-Barr virus and the use thereof

The present invention concerns a polypeptide which is composed of the amino acids 1207&#xb1;10 to 1488&#xb1;10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.

Method for determining early HCV seroconversion

Various immunologically active proteins fromhave been prepared by genetic manipulation in microorganisms. To do this, the specific DNA sequences were selected from agene bank using suitable screening methods, or were prepared directly by DNA amplification using selected hybridization probes, and were placed under the control of inducible promoters such as, for example, the lac promoter. It has been possible, owing to description of efficient purification methods for the expressed antigens, to provide the proteins in a suitable way. These proteins can be used to produce specific and sensitive diagnostic assay kits. The specific combination of the immunologically active proteins makes precise diagnosis possible. Furthermore, monoclonal antibodies have been generated and are used as reagents for detecting pathogens directly in test samples or after cultivation. The-specific DNA sequences can be employed for direct detection of the pathogen in patients' samples (for example by means of the PCR reaction).

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Immunologically active proteins from Borrelia burgdorferi, nucleic acids which encode them, and their use in test kits and as vaccines

Various immunologically active proteins from have been prepared by genetic manipulation in microorganisms. To do this, the specific DNA sequences were selected from a gene bank using suitable screening methods, or were prepared directly by DNA amplification using selected hybridization probes, and were placed under the control of inducible promoters such as, for example, the lac promoter. It has been possible, owing to description of efficient purification methods for the expressed antigens, to provide the proteins in a suitable way. These proteins can be used to produce specific and sensitive diagnostic assay kits. The specific combination of the immunologically active proteins makes precise diagnosis possible. Furthermore, monoclonal antibodies have been generated and are used as reagents for detecting pathogens directly in test samples or after cultivation. The &mdash;specific DNA sequences can be employed for direct detection of the pathogen in patients' samples (for example by means of the PCR reaction).

Immunologically active proteins from Borrelia burgdorferi

Various immunologically active proteins from have been prepared by genetic manipulation in microorganisms. To do this, the specific DNA sequences were selected from a gene bank using suitable screening methods, or were prepared directly by DNA amplification using selected hybridization probes, and were placed under the control of inducible promoters such as, for example, the lac promoter. It has been possible, owing to description of efficient purification methods for the expressed antigens, to provide the proteins in a suitable way. These proteins can be used to produce specific and sensitive diagnostic assay kits. The specific combination of the immunologically active proteins makes precise diagnosis possible. Furthermore, monoclonal antibodies have been generated and are used as reagents for detecting pathogens directly in test samples or after cultivation. The -specific DNA sequences can be employed for direct detection of the pathogen in patients' samples (for example by means of the PCR reaction).

The present invention concerns a polypeptide which is composed of the amino acids 1207&plusmn;10 to 1488&plusmn;10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.

Recombinant antigen from the NS3 region of the hepatitis C virus

Immunologically active peptides or polypeptides with a partial amino-acid sequence of the capsid proteins VP1 and VP2 of parvovirus B19 which permit tests to be carried out at low cost, sensitively and specifically for the determination of antibodies against human parvovirus B19 are made available. Short peptide sequences which, employed as antigen, serve to identify anti-B19 IgG-positive sera are identified. Furthermore, the production of these peptides using genetic engineering measures is disclosed. Other antigens which are produced by genetic engineering and which can be stably produced in a high yield in,and subsequently purified therefrom are used as additional antigens for IgG detection. Finally, a set of antigens permits tests to be carried out to determine IgM antibodies against the virus. In addition, the components, produced by genetic engineering, of the surface proteins represent substances which can be used for prophylactic immunisation.

Immunologically active peptides or polypeptides from the parvovirus B19

Various immunologically active proteins from,have been prepared by genetic manipulation in microorganisms. To do this, the specific DNA sequences were selected from a,gene bank using suitable screening methods, or were prepared directly by DNA amplification using selected hybridization probes, and were placed under the control of inducible promoters such as, for example, the lac promoter. It has been possible, owing to description of efficient purification methods for the expressed antigens, to provide the proteins in a suitable way. These proteins can be used to produce specific and sensitive diagnostic assay kits. The specific combination of the immunologically active proteins makes precise diagnosis possible. Furthermore, monoclonal antibodies have been generated and are used as reagents for detecting pathogens directly in test samples or after cultivation. The,-specific DNA sequences can be employed for direct detection of the pathogen in patients' samples (for example by means of the PCR reaction).

Immunologically active PC proteins from Borrelia burgdorferi

Active proteins from Borrelia burgdorferi

Polypeptides derived from proteins of the hepatitis C virus, test kits

The present invention concerns a polypeptide which is composed of the amino acids 1207.+-.10 to 1488.+-.10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.

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Munich, Germany

Manfred Motz