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Carl Zeiss Microscopy Gmbh

Manfred Loth

Frank Klemm

Mirko Liedtke

Albrecht Geist

A method for recording pulse signals which allows the reconstruction of a time reference. The time of every pulse signal event can be determined by counting sampling result bits preceding the respective sampling result bit using the known sampling frequency. For this purpose, every period of the sampling frequency is associated with a bit representing the respective sampling result and the sampling result bits are stored one by one and per channel in data blocks. The sampling frequency is preferably higher than a pixel clock, a sampling result bit associated with a flank of the pixel clock being marked. The pixel clock can thus be synchronized with the individual events exactly per sampling period. The invention further relates to the field of fluorescence correlation spectroscopy using confocal microscopes or laser scanning microscopes.

Method for recording pulse signals

A process for recording pulse signals of at least two input channels includes sampling the input channels with a predetermined sampling frequency for events which have occurred, and after detection of an event in at least one of the input channels, or after overflow of a counter, storing the present state of all the input channels in a memory register together with a magnitude characterizing a time interval to the last storage operation. The device for recording pulse signals of at least two input channels according to the process includes a clock oscillator, a sampler that samples the input channels, a counter, and a memory. The detection of a first event in one of the input channels or the overflow of the counter, according to which event occurs first, triggers and operation of storage of the states of all the input channels and of the last counter state at the occurrence of the event.

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Kleinschwabhausen, Germany

Manfred Loth