American Home Products Corporation

Ayerst, Mckenna & Harrison, Inc.

Manfred K Gotz

Hans U Immer

Amedeo Failli

Jean-Marie Ferland

Verner R Nelson

Kazimir Sestanj

The N-substituted dimeric cyclopeptide derivatives of formula ##STR1## in which A is a peptide residue having one to four amino acid residues; R.sup.1 is lower alkyl, phenyl or phenyl(lower)alkylene; R.sup.2 is lower alkyl, cyclo(lower)alkyl or lower alkoxycarbonyl(lower)alkylene; and R.sup.3 is a neutral amino acid side chain and a method for the preparation of the compounds of formula I are disclosed. The compounds of formula I are useful for treating microbial infections. Pharmaceutical compositions also are disclosed.

N-Substituted dimeric cyclopeptide derivatives

The N-substituted cyclopeptide derivatives of formula I ##STR1## in which R.sup.1 is lower alkyl, R.sup.2 is lower alkyl or cyclo(lower)alkyl, R.sup.3 is a neutral amino acid side chain and Y is a peptide residue having three to nine amino acid residues and a method for the preparation of the compounds of formula I are disclosed. The compounds of formula I are useful antibacterial and antifungal agents. Pharmaceutical compositions also are disclosed.

N-Substituted cyclopeptide derivatives

The N-substituted dimeric cyclopeptide derivatives of formula ##STR1## in which A is a peptide residue having one to four amino acid residues; R.sup.1 is lower alkyl, phenyl or pheny(lower) alkylene; R.sup.2 is lower alkyl, cyclo(lower)alkyl or lower alkoxycarbonyl(lower)alkylene; R.sup.3 is a neutral amino acid side chain and a method for the preparation of the compounds of formula I are disclosed. The compounds of formula I are useful for treating microbial infections. Pharmaceutical compositions also are disclosed.

N-substituted dimeric cyclopeptide derivatives and preparation thereof

N-substituted cyclopeptide derivatives and preparation thereof

A process for preparing the LH- and FSH-releasing hormone of the formula I

Process for preparing the releasing hormone of luteinizing hormone (LH)

Dipeptide derivatives with central nervous system activity and

Pyridylmethyl esters of N-(phenoxyalkanoyl)peptide derivatives are disclosed. The derivatives are characterized by having a phenoxyalkanoyl group and a pyridylmethyloxy group-joined together by a peptide group. They possess antihyperlipoproteinemic activity. In addition, methods for their preparation and use are disclosed.

Pyridylmethyl esters of N-(phenoxyalkanoyl)peptide derivatives

Tripeptide derivatives with central nervous system activity and

There are disclosed herein derivatives of imidazolidin-2-ones and -2-thiones of the formula I ##SPC1## and their acid addition salts with pharmacologically acceptable acids, in which R.sup.1 is hydrogen or lower alkyl; R.sup.2 is lower alkyl, nitrothiazolyl, or nitrofuryl; or R.sup.1 and R.sup.2 together with the nitrogen to which they are attached are a heterocyclic group containing 4-6 carbon atoms, or 4 carbon atoms and an additional nitrogen atom which may optionally be substituted with a lower alkyl group, or 4 carbon atoms and an oxygen atom, R.sup.3 is hydrogen or lower alkyl; R.sup.4 is lower alkyl or aralkyl, or R.sup.3 and R.sup.4 together with the carbon atom 5 of the imidazolidine ring to which they are attached are a carbocyclic ring containing 5-6 carbon atoms attached in spiro fashion to said imidazolidine ring; R.sup.5 is lower alkyl or cycloalkyl containing from 5-6 carbon atoms; and X is an oxygen or a sulfur atom. The compounds of this invention possess positive inotropic activity and are useful as cardiac stimulants.

Growing community of inventors

Hudson, Canada

Manfred K Gotz