Trigen Gmbh

Thrombosis Research Institute

Manfred Hans Philipp

Goran Karl Claeson

Rainer Metternich

Pharmaceutical compositions comprising compounds of the formula: ##STR1## in which X.dbd.H or is an N-protecting group; Y is 1-10 .alpha.-amino acids; Q1 and Q2 taken together represent the residue or a diol; R is C.sub.1-4 alkyl; and the asymmetric carbon atom marked * may have the D- or L-configuration, are useful in therapeutic methods of inhibiting thrombin.

Inhibitors of trypsin-like enzymes

Pharmaceutical compositions comprising compounds of the formula: ##STR1## in which X=H or is an N-protecting group; Y is Phe-Pro; Q1 and Q2 taken together represent the residue of a diol; R is C.sub.1-4 alkyl; and the asymmetric carbon atom marked * may have the D- or L- configuration, are useful in therapeutic methods of inhibiting thrombin.

Growing community of inventors

Scarsdale, NY, United States of America

Manfred Hans Philipp