Hyglos Invest Gmbh

Biomerieux Sa

Manfred Biebl

Holger Grallert

Stefan Miller

Renate Grassl

Roman Meyer

Anja Philipp

Michael Forchheim

Monika Walter

The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Caor Mg. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.

Nucleic acids encoding bacteriophage tail proteins

The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci.

Proteins for use in human and animal staphylococcus infections

Method for detecting and removing endotoxin

Bacteriophage adhesion proteins binding to the O-antigen of gram negative bacteria, but lacking the ability of binding to a bacteriophage and of hydrolysing lipopolysaccharides, are described, as well as nucleic acid molecules encoding the proteins. In addition, methods for generating the bacteriophage adhesion proteins and their use in detection, purification and enrichment of bacteria are described.

Bacteriophage adhesion proteins

Proteins for use in human and animal Staphyococcus infections

The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to

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Wuppertal, Germany

Manfred Biebl