Agilent Technologies, Inc.

Hewlett-packard Company

Other

Caliper Technologies Corporation

Caliper Life Sciences, Inc.

Manfred Berndt

Colin B Kennedy

Konstantin Shoykhet

Patrick Kaltenbach

Tony Ziegler

Ralf-Peter Peters

Klaus E Witt

Thomas Ortmann

Daniel Thielsch

Joachim-Richard Wagner

Juergen Siegfried Skott

Uwe Effelsberg

Clemens Plachetka

Mario Hempel

Zeno Rummler

Darijo Zeko

Thomas Reinhardt

Volker Brombacher

Jose-Angel Mora-Fillat

Michael Braun

Bernd Glatz

Raoul Dinter

Marcus Gassmann

Werner Schomburg

Soeren Groth

Garrett Unno

Jan Eickhoff

Mark Goellner

Sven Langer

Matthias Wetzel

Werner Karl Schomburg

Bernd Nawracala

Guenter Gauglitz

Bernd Schaupp

Dieter Graefe

Gunther Elender

Guenter Berthel

A fluid supply device for providing a mobile phase for a sample separating device includes, a supply conduit for providing a fluid which forms at least a part of the mobile phase, a fluid valve which is fluidically coupled with the supply conduit and, depending on its switching state, enables or prevents a passing of the fluid from the supply conduit, an elastic buffer unit which is fluidically coupled upstream of the fluid valve with the supply conduit and which is configured for buffering the fluid, and a fluid conveying unit for conveying the fluid which passes the fluid valve.

Fluid supply devices and fluid member for forming a mobile phase for a sample separating device

A mixer for mixing a mobile phase in a sample separation device for separating a fluidic sample, wherein the mixer includes a fluid inlet for supplying the mobile phase to be mixed to a mixing volume, a movable body configured for rotating and axially moving in the mixing volume to thereby mix the mobile phase, and a fluid outlet for supplying the mixed mobile phase to a mobile phase consumer.

Mixing fluid by combined axial motion and rotation of mixing body

A valve arrangement includes a valve module and a base module. The valve module includes a stator and a rotor, which is rotatable relative to the stator such that at least one fluid connection is formable between the stator and the rotor. The base module includes at least a part of a force control mechanism for selectively implementing a force-releasing or force-coupling of the rotor and the stator, whereby the valve module and the base module are selectively coupleable to or decoupleable from each other.

Valve arrangement having valve module and base module

A fluidic valve for switching between different fluid coupling states includes a stator having at least one fluidic stator interface, a rotor having at least one fluidic rotor interface, wherein the rotor is rotatable relative to the stator to thereby switch the fluidic valve between a plurality of different fluid coupling states between the at least one fluidic stator interface and the at least one fluidic rotor interface, and a force transmission mechanism configured for pressing the stator and the rotor together by a contactless force transmission to provide for a fluid tight sealing between the stator and the rotor.

Fluidic valve with contactless force transmission for pressing together stator and rotor

A fluidic device includes a planar structure constituted by a plurality of laminated layers and accommodating a fluid channel extending up to a surface of the planar structure, and a female adapter piece configured for a fluid-tight accommodation of a male adapter piece having a fluid conduit. The the female adapter piece is connected or connectable with the planar structure so that, when the male adapter piece is accommodated in the female adapter piece, the fluid conduit is brought in fluid-tight fluid communication with the fluid channel. The fluid channel is exposed to the female adapter piece at a lateral surface of the planar structure at which the laminated layers are exposed.

Integrated fluidic connection of planar structures for sample separation devices

Disclosed is a sample dispatcher configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a separation system configured for separating compounds of the sample fluids. The separation system comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises a plurality of sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof. The sample dispatcher is configured for selectively coupling one of the plurality of sample reservoirs between the mobile phase drive and the separation unit, and further for coupling at least two of the plurality of sample reservoirs in parallel between the mobile phase drive and the separation unit.

HPLC sample introduction with coupling sample reservoirs in parallel between mobile phase drive and separation unit

A shear valve, for use in a high performance liquid chromatography system, comprises a first shear valve member and a second shear valve member. At least one of the first and second shear valve members is adapted to be moved with respect to the other. One of the first and second shear valve members comprises a plurality of ports, and the other comprises at least one fluid path for fluidly coupling respective ones of the ports in dependency on a relative movement position of the first and second shear valve members with respect to each other. The first shear valve member is at least partially coated with or comprised of silicon carbide.

Shear valve with silicon carbide member

A supporting plate of a device is suggested. The device has at least one component and a housing for at least partly protecting the component. The supporting plate has at least one receiving element adapted for accepting the at least one component of the device in at least one of the following manners: in a form-closed manner, in a force-closed manner. The supporting plate is part of the housing.

Supporting plate of a device

A shear valve for use in a high performance liquid chromatography system, the shear valve comprising a first shear valve member and a second shear valve member, wherein at least one of the first and second shear valve members is adapted to be moved with respect to the other, one of the first and second shear valve members comprises a plurality of ports, and the other comprises at least one fluid path for fluidly coupling respective ones of the ports in dependency on a relative movement position of the first and second shear valve members with respect to each other, wherein the first shear valve member is at least partially coated with an adhesion-promoting layer and a diamond like carbon layer on the adhesion-promoting layer.

Shear valve with DLC comprising multi-layer coated member

A cover for sealing a container and preferably containers for a well plate. The cover is comprised of at least a top layer and a bottom layer structured in a way to form a recloseable aperture. Preferably, each of the layers comprise a recloseable aperture structured as flap, damper, baffle or butterfly valve respectively, wherein the recloseable apertures are arranged on top of each other. In a preferred embodiment of the invention a third moveable layer is arranged between the top and the bottom layer. By moving the middle layer, the aperture in the cover can be closed.

Cover with recloseable aperture

A microfluidic assembly () has at least one microfluidic flow path () and at least one inlet port () coupled to the flow path (). The microfluidic assembly () has a first microfluidic device () that executes a microfluidic process and has a second microfluidic device (). The microfluidic assembly () has an interface (). The interface () couples the first microfluidic device () and the second microfluidic device ().

Microfluidic assembly with coupled microfluidic devices

A fluidic device comprising a capillary for conducting a fluid and a pivot arm configured for being pivoted, wherein the pivot arm supports at least a portion of the capillary, and a part of the capillary is coiled to at least partially compensate stress resulting from pivoting of the pivot arm.

Coiled capillary for compensating mechanical stress

In a system for operation or handling of a laboratory microchip () for chemical processing or analysis, the microchip () is mounted in a first physical unit (). The microchip () is arranged on a mounting plate, such that it is readily accessible from the top and thus the fitting and removal of the microchip is considerably simplified. Furthermore, the first physical unit () comprises an optical device () for contactless detection of the results of the chemical processes conducted on the microchip. The supply systems necessary for the operation of the microchip are arranged in a module unit that has a separable connection with a second physical unit. The proposed modular layout enables ease of interchangeability of the required supply systems and thus, overall, ease of adaptability of the proposed system for various types of microchips.

Apparatus for the operation of a microfluidic device

In a device to operate and handle a laboratory microchip to chemically process or analyze substances, the microchip is on a chip holder () that is part of a first assembly (). The first assembly () also has an optical device () for contactless detection of the results of the chemical processes carried out on the microchip. A supply device () required to operate the microchip is in a module releasably connected to a second assembly (). In particular, the second assembly () has an intermediate carrier () that is releasably connected to the supply device (). The intermediate carrier has continuous electrical paths () or connecting channels that can bridge electrodes () or supply channels of the supply device () and the assigned counterelectrodes () of the microchip. There are correspondingly connecting lines () to bridge the supply of materials. On the one hand, the bridging serves to prevent wear and soiling of the supply device () electrodes that arises upon contacting the microchip. In addition, the intermediate carrier also serves to spatially adapt the electrodes of the supply device () to the respective surface or spatial arrangement of the electrode surfaces of the microchip. It is thereby advantageously possible to adapt the entire measuring or operating device to special microchip layouts merely by exchanging the intermediate carrier ().

Device to operate a laboratory microchip

Growing community of inventors

Karlsruhe, Germany

Manfred Berndt