Roche Diagnostics Operations, Inc.

Boehringer Mannheim Gmbh

Roche Operations Ltd.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Manfred Augstein

Stefan Riebel

Gregor Bainczyk

Herbert Wieder

Friedrich Karl Ackermann

Christoph Boehm

Blaine Edward Ramey

Matthew Carlyle Sauers

Joerg Dreibholz

Bruno Robert Thoes

Susanne Wuerl

Robert Paul Sabo

Oliver Kube

Timothy L Beck

Dieter Meinecke

Frederick Leland Wittekind, Iii

Wolfgang Walter

Seth Faulkner Williams

Joerg Schreiber

Albert Grosser

Wolfgang Fabian

Carlo S Effenhauser

Juergen Spinke

Phillip Edgar Pash

Volker Unkrig

Thorsten Brueckner

Michael Schabbach

Edwin Oosterbroek

Volker Gerstle

Nadine Losleben

Rijk Edwin Oosterbroek

Jürgen Spinke

Robert Lawrence Meek

Markus Stephan Fuerst

Guido Abel

Udo Manser

Valerie Winckler-Desprez

Bruno Thös

Romi Roedl

Philip Edgar Pash

Firedrich Karl Ackermann

Heinz Macho

Uwe Kass

Dieter Falk

Rainer Stöhar

Thorsten BRÜCKNER

Christoph BÖHM

Susanne WÜRL

Seeth Faulkner Williams

Frederick Leland Iii Wittekind

Rainer STÖHR

A method of performing a measurement of an analyte in a sample using an automatic analyzer is provided. The automatic analyzer comprises: a cartridge for dispensing a fluid, a measurement unit for performing the measurement, a sample holder for receiving the sample, and a pump for pumping the fluid out of the cartridge and into the sample holder. The cartridge comprises: a rigid portion, a flexible bladder, and an outlet. The rigid portion comprises an opening, which is connected to an inner cavity. The flexible bladder seals the opening to form a fluid chamber from the inner cavity. The fluid chamber is at least partially filled with the fluid. The pump is connected to the outlet. The method comprises: placing the sample into the sample holder, controlling the pumping of the fluid from the cartridge into the sample holder, and performing the measurement of the analyte using the measurement unit.

Method to perform a measurement of an analyte in a sample using an automatic analyzer

The invention concerns a test element analytical system for the analytical examination of a sample, especially a body fluid, comprising at least one test element with one or more measuring zones and contact areas located on the test element, in particular electrodes or conductor paths, the sample to be examined being brought into the measuring zone to carry out an analysis in order to determine a characteristic measured quantity for the analysis, and an evaluation instrument with a test element holder for positioning the test element in a measuring position and a measuring device for measuring the characteristic change, the test element holder containing contact elements with contact areas which enable an electrical contact between the contact areas of the test element and the contact areas of the test element holder, characterized in that one of these contact areas is provided with an electrically conductive hard material surface.

Test element analysis system with contact surfaces coated with hard material

A method for producing a plastic injection-molded part having an insert made of a material different from the plastic material is provided, the method comprising the steps of: (a) introducing and positioning the insert in a cavity of an injection mold; (b) setting the clamping force of the injection mold on a clamping mechanism to a maximum force predetermined by the material of the insert; and (c) seamlessly encapsulating the insert with the plastic material of the plastic injection-molded part inside the injection mold, wherein the encapsulating is seamless or complete.

Plastic injection-moulded part with embedded component

A microfluidic test carrier having a substrate, covering layer, and capillary structure formed in the substrate is provided. The capillary structure is enclosed by the substrate and covering layer and comprises a receiving chamber, sample chamber and connection channel between the receiving and sample chambers. The receiving chamber has two boundary surfaces and a side wall, wherein one boundary surface forms the bottom and the other forms the cover. The receiving chamber has a surrounding venting channel and dam between the receiving chamber and venting channel. The dam and venting channel form a capillary stop configured as a geometric valve, through which air from the receiving chamber can escape into the venting channel. The connecting channel between the venting channel outflow and sample chamber inflow controls fluid transport from the receiving chamber into the sample chamber. The capillary stop is configured to prevent autonomous fluid transport from the receiving chamber.

Microfluidic test carrier for apportioning a liquid quantity into subquantities

A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.

Microfluidic element for analyzing a liquid sample

A method for providing a dried reagent in a microfluidic system is provided, the method comprising the following steps: providing a microfluidic system having a microfluidic structure, introducing a flowable carrier medium containing a reagent in the microfluidic structure, and drying the reagent in the microfluidic structure by lyophilization.

Method for providing a dried reagent in a microfluidic system and microfluidic system

Apparatuses and methods thereof to administer and manage a base unit for a handheld medical device are disclosed. In one embodiment, a base unit of the invention is in communication with a handheld medical device. The base unit is configured to provide an electrical connection to a power source to charge a battery of the handheld medical device. The base unit is also configured to perform an update to the operation of the base unit, wherein the update is initiated by the base unit upon receiving from the handheld medical device a data stream with information indicating that an update is contained in the data stream.

Apparatus and method to administer and manage an intelligent base unit for a handheld medical device

An analysis device for analysis of a sample on a test element is provided that comprises at least one component configured to make electrical contact with at least one other component for electrical transmission therebetween. The at least one component generally comprises an injection-molded circuit mount, also called an MID, or molded interconnect device.

Device for analysis of a sample on a test element

An electrical connection system for an analysis system and a method for analysis of a liquid sample on an analytical test element using the described analysis system are disclosed. The analysis system provides an evaluation appliance for evaluation of electrical signals, a test element holder for holding and positioning of an analytical test element in a measurement position, and an electrical contact element which makes electrical contact with an electrical contact surface of an analytical test element to produce an electrical connection between the contact surface and the evaluation appliance. The contact element is moved by means such that contact with the electrical contact surface of the test element is made when the test element holder is in the measurement position.

Electrical connection system for an electrochemical analysis system

Apparatuses and methods providing data such as, for example, calibration and reagent information () over a network () to a measurement apparatus () which makes use of a consumable reagent () in a measuring process are disclosed. The present invention permits a measurement apparatus () to download the necessary code assignment () and calibration data () of the consumable reagent () by means of an electronic communication protocol from a host (). The host () can be a software application running on a host computer (), another measurement apparatus () with or without a code-key slot used to read a memory device providing the above mentioned information (), a dedicated connectivity device, such as a docking station (), a portable memory reader (), a remote computer (), and combinations thereof.

Host apparatus and method providing calibration and reagent information to a measurement apparatus which makes use of a consumable reagent in a measuring process

A device for sampling liquid samples is provided comprising a capillary-active channel, a sampling site, and a determination site. The capillary-active channel is configured for transporting a sample from the sampling site to the determination site. The capillary-active channel is substantially formed by a carrier, a cover and an intermediate layer located between the carrier and cover. The carrier protrudes beyond the cover in the area of the sampling site. The intermediate layer is displaced towards the back in the direction of the determination site in the area of the sampling site so that the carrier as well as the cover protrude beyond the intermediate layer. The device allows sample to be applied from above onto the exposed area of the carrier in the area of the sampling site and also allows sample to be applied from the side.

Sampling device for liquid samples

An electronic device enclosure having an integrated in-mold foil, which prevents fluid ingress around an included display of the electronic device, is disclosed. A portion of the in-mold foil is adapted to the specific contour and profile of the display, thereby allowing a user to use a touch screen interface of the display with no shortcomings. In addition, the in-mold foil protects the display from direct chemical attack, and may provide a liquid-tight seal between a button of the electronic device and the enclosure.

Enclosure to prevent fluid ingress of a device having a touch screen interface

The invention relates to the field of modular analytical systems. The invention enables the topology of a modular analytical system to be determined without requiring additional complicated measures such as a system reset. The method/system is also adapted to industry standards such that CAN-busses can be used.

Method and system for determining the topology of a modular analysis system

Growing community of inventors

Mannheim, Germany

Manfred Augstein