Merck Sharp + Dohme Corp.

Orchid Chemicals & Pharmaceuticals Limited

Orchid Pharma Ltd.

Allecra Therapeutics Gmbh

Maneesh Paul-Satyaseela

Gopalan Balasubramanian

Senthilkumar Udayampalayam Palanisamy

Hariharan Periasamy

Ravi P Nargund

Sriram K Rajagopal

Michael W Miller

Sheo B Singh

Shuzhi Dong

Katherine Young

Hongwu Wang

Shridhar Narayanan

Venkatesan Parameswaran

Andrew Gnanaprakasam

Aravind Appu

Bharani Thirunavukkarasu

Senthilnathan Manickam

Prabhakar Rao Gunturu

Palanisamy Senthilkumar Udayampalayam

Panchapakesan Ganapathy

Chidambaram Venkateswaran Srinivasan

Manjula Devi Deshkumar

Mukut Gohain

Venkatasubramanian Hariharan

Venkateshwarlu Jakkala

Shakti Singh Solanki

Sridhar Ramanathan Iyer

Sathishkumar Devarajan

Michael Wayne Miller

Michael Miller

Hariharan Venkatasubramanian

Gohain Mukut

Rajagopal Sriram

Sheo Singh

This invention relates to carbapenem compounds of the following formula: wherein A, Z, X, R, and Rare as described herein, as well as stereoisomers, pharmaceutically acceptable salts or N-oxides thereof, which may be useful for the treatment of bacterial infections, particularly drug-resistant bacterial infections, as well as the processes for the preparation of compounds, the pharmaceutical compositions of these compounds and their use in the treatment of bacterial infection.

Substituted carbapenems for the treatment of bacterial infections

Described herein are compounds and their use in the treatment of infections. The compound of formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and pharmaceutical compositions described herein are also useful as &#x3b2;-lactamase inhibitors, which restore or enhance the antibiotic spectrum of a suitable antibiotic agent. The compounds of formula (I) act as inhibitors of &#x3b2;-lactamases. These compounds restore/potentiate the activities of &#x3b2;-lactam antibiotics against carbapenemases. These compounds find use in diagnostic method for detecting &#x3b2;-lactamases. Formula (I) 

Compounds and their use

Novel 2-substituted methyl penam derivatives include the formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their solvates, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them; wherein A=C or N; Het is a three- to seven-membered heterocyclic ring; Rrepresents carboxylate anion, or &#x2014;COORwhere Rrepresents hydrogen, carboxylic acid protecting group or a pharmaceutically acceptable salt; Rand Rmay be same or different and independently represent hydrogen, halogen, amino, alkyl, protected amino, optionally substituted alkyl, alkenyl, alkynyl and the like; R represents substituted or unsubstituted alkyl, alkenyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heterocyclylalkyl.

2-substituted methyl penam derivatives

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Chennai, India

Maneesh Paul-Satyaseela