Dsm IP Assets B.v.

Mandy Maria Jozefina Wiermans

Nicolaes Hubertus Maria De Bont

Noel L Davison

Roelof R Marissen

Mischa Nelis

Mark Kenneth Hazzard

Marc Linssen

Loes Heleen Pluymen

Disclosed herein are composite sheets and prosthetic medical devices formed therefrom. In an embodiment, a composite sheet has a thickness of 25-250 μm and comprises 10-70 mass %, based on the total mass of the composite sheet, of a knit fabric having thickness of 15-225 μm and comprising strands of 2-50 dtex, the strands comprising biocompatible polymer fibers, the strands comprising biocompatible polymer fibers, wherein the fabric comprises a thickness in a plurality of first locations, and pores in a plurality of second locations; and 30-90 mass %, based on the total mass of the composite sheet, of a polyurethane coating, wherein the polyurethane coating coats the fabric and fills the pores of the fabric such that the composite sheet is substantially impermeable to water.

Composite sheets and medical implants comprising such sheets

Disclosed herein is a polyurethane composite sheet comprising o a biocompatible and biostable polyurethane elastomer comprising polysiloxane segments, the polyurethane forming a continuous matrix of the sheet; and o a woven or braided fabric having a thickness of 15-150 μm and comprising biocompatible, high-strength polymer fibers; wherein the composite sheet comprises 10-90 mass % of polyurethane, has a thickness of 25-250 μm and an areal density of 5-300 g/m; and wherein the composite sheet has, in at least one direction, non-linear uniaxial tensile behavior characterized by a 1%-secant modulus of 20-200 MPa, a hardening transition point at 10-45%, and a tensile strength of at least 25 MPa (measured in water at 37° C.).

Polyurethane composite sheet, a method of making such composite sheet, and use thereof in making a medical implant

Disclosed herein is a medical implant component comprising a composite biotextile, which biotextile comprises i) a polyolefin fibrous construct comprising at least one strand with titer of 2-250 dtex, tensile strength of at least 10 cN/dtex and comprising high molar mass polyolefin fibers and ii) a coating comprising a biocompatible and biostable polyurethane elastomer comprising a polysiloxane segment and/or having one or more hydrophobic endgroups, wherein the polyurethane coating is present on at least part of the surface of the biotextile and in an amount of 2.5-90 mass % based on composite biotextile. Such composite biotextile, like a partly coated woven fabric, shows an advantageous combination of good biocompatibility, especially hemocompatibility, high strength and pliability, and laser cuttability; allowing to make pieces of fabric having well-defined regular edges that have high suture retention strength. The invention also provides a method of making said composite biotextile. Further embodiments concern the use of such biotextile in or as medical implant component for an implantable medical device and the use of such medical implant component in making an implantable medical device; such as in orthopedic applications and cardiovascular implants. Other embodiments include such medical devices or implants comprising said medical implant component.

Medical implant component comprising a composite biotextile

Disclosed herein is a method of making a composite fabric for use in or as a medical implant component, the method comprising steps of providing a textile comprising at least one strand having titer of 2-250 dtex and comprising fibers made from a biocompatible and biostable synthetic polymer; determining locations on the textile where a cut is to be made for an intended use of the textile; optionally pretreating the textile at least at the determined locations on at least one side of the textile with a high-energy source to activate the surface; solution coating the textile at least at a determined location with a coating composition comprising a biocompatible and biostable polyurethane elastomer and a solvent for the polyurethane; removing the solvent from the coated textile; and laser cutting the coated textile as obtained at least a one coated location with an ultra-short pulse laser; to result in a composite biotextile wherein polyurethane is present in an amount of 2.5-90 mass % based on composite biotextile and polyurethane is present at least at a laser-cut edge. Such composite biotextile as made shows an advantageous combination of good biocompatibility, especially hemocompatibility, high strength and pliability, and has well-defined regular edges that have high suture retention strength. Further embodiments concern the use of such composite biotextile in or as medical implant component for an implantable medical device; such as in orthopedic applications and cardiovascular implants. Other embodiments include such medical devices or implants comprising said composite biotextile or medical implant component.

Method of making a composite biotextile and a medical implant comprising such composite biotextile

Disclosed herein is a porous hybrid elastomer/polyolefin film, which is a porous polyolefin film wherein at one or more isolated areas of the film pores are at least partly filled with an elastomer. This hybrid film shows improved resistance to tearing, whereas other properties like porosity, polarity, thickness, flexibility, and non-stickiness of the film are substantially retained. Other advantages include improved suture retention. The invention also provides a method to increase tear resistance of a porous polyolefin film comprising steps of providing a porous polyolefin film; identifying one or more locations on the film, at which locations tearing is likely to occur during intended use of the film; applying at the identified locations of the film an amount of a solution of an elastomer in solvent; and substantially removing the solvent; to result in a hybrid elastomer/polyolefin film having one or more isolated areas where pores in the film are at least partly filled with the elastomer. Further aspects concern uses of these hybrid films as a component of a medical implant or device, especially for use in contact with body tissue or fluids, such as in vascular applications like a vascular graft, a stent cover or a catheter balloon; and medical devices or implants comprising said porous hybrid films.

Modified porous polyolefin film and method of making

Multifilament yarn constructions include a core part and a sheath part, the core part comprising a plurality of core filaments, and the sheath part comprising a plurality of sheath filaments. Furthermore, members comprising the multifilament yarn construction and uses of the multifilament yarn construction and the members are provided.

Multifilament yarn construction

The invention concerns a multifilament yarn construction comprising a core part and a sheath part, the core part comprising a plurality of core filaments, and the sheath part comprising a plurality of sheath filaments. Furthermore, the invention concerns members comprising the multifilament yarn construction and uses of the multifilament yarn construction and the members according to the invention.

Growing community of inventors

Geleen, Netherlands

Mandy Maria Jozefina Wiermans