Piramal Enterprises Limited

Mandar Bhonde

Sanjay Kumar

Nilesh Dagia

Kalpana Sanjay Joshi

Rajiv Sharma

Asha Adrian Kulkarni-Almeida

Sapna Parikh

Maggie Rathos

Sivaramakrishnan Hariharan

Vijaykumar Bhagwan Deore

Pramod Bhaskar Kumar

Nilambari Nilkanth Yewalkar

Pallavi Hanmantrao Mane

Amol Arun Padgaonkar

The present invention relates to compounds of formula (I), wherein R, R, R, R, Rand Rare as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases mediated by phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR), Signal transducer and activator of transcription 3 (STAT 3), tumor necrosis factor-&#x3b1; (TNF-&#x3b1;), interleukin-6 (IL-6) or a combination thereof particularly in the treatment of cancer and inflammation.

Imidazopyridine derivatives

The present invention relates to pyridyl derivatives capable of inhibiting phosphatidylinositol-3-kinase (PI3k), mammalian target of rapamycin (mTOR) and/or hypoxia inducible factor 1&#x3b1; (HIF-1&#x3b1;) mediated signaling. Also disclosed are processes for preparation of the pyridyl derivatives, and their use in the manufacture of pharmaceutical compositions for the treatment of clinical conditions caused by deregulation of signaling pathways selected from one or more of PI3K, mTOR and HIF-1&#x3b1; pathways. The pyridyl derivatives are also useful for the treatment of conditions or disorders mediated by TNF-&#x3b1;.

Pyridyl derivatives, their preparation and use

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Pune, India

Mandar Bhonde