Shiseido Company, Limited

The General Hospital Corporation

Other

Manami Ohnuma

Masahiro Tajima

Ethan A Lerner

Kawori Wakita

Osamu Moro

Masaru Suetsugu

Yoshihiro Morikawa

Yuki Yamase

Kenji Kitamura

Naoe Akiyama

Ethan L Lerner

There are provided a method to screen agonist or antagonist of the maxadilan receptor participating in vasodilating action, wherein a receptor of maxadilan is used, compounds which specifically bind to the receptor, and a tissue preparation having the receptor. The compounds are variants of maxadilan from the salivary glands of the sand fly.

Method for screening agonist or antagonist of the maxadilan receptor participating in vasodilating action, and compound found by the method

This specification relates to the use of peptides having a specific affinity to pituitary adenylate cyclase activating polypeptide (PACAP) receptors, particularly MAX (67 amino acids), NSP (61 amino acids) and M65 (46 amino acids). MAX and NSP act as agonists to PACAP type 1 receptors, and M65 acts as an antagonist to PACAP type 1 receptors.

Peptides having specific affinity to pituitary adenylate cyclase

An external preparation for skin including one or more than two types of tranexamic acid derivatives represented by the following general formula (A). GENERAL FORMULA (A) ##STR1## (In the formula (A), R.sub.1, R.sub.2 and R.sub.3 represents hydrogen atoms or substituents and at least one of these is the substituent.) The external preparation for skin including the derivatives have excellent depigmentation effect as well as skin care effect.

External preparation for skin

A modified maxadilan protein exhibits higher biological activity than native maxadilan from the sand fly Lutzomyia longipalpis. A modified maxadilan fusion protein contains a thrombin cleavage site. This enables the production of the modified maxadilan as a fusion protein and recovery of the modified maxadilan after digestion with thrombin. The modified maxadilan is a potent vasodilator.

Modified maxadilan protein, its preparation and use, and DNA encoding

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Kamakura, Japan

Manami Ohnuma