Medinet Co., Ltd.

Manami Isogai

Mie Nieda

Kazuhiro Kakimi

Masashi Takahara

Andrew Nicol

Activated antigen-presenting cells that can induce immunocytes including disease antigen-specific CD8+ CTLs and/or &#x3b3;&#x3b4; T cells efficiently in vivo and/or in vitro, a medical composition comprising the activated antigen-presenting cells, a treatment and prevention method using the activated antigen-presenting cells, and an induction method of immunocytes including disease antigen-specific CTLs and/or &#x3b3;&#x3b4; T cells induced using the activated antigen-presenting cell, immunocytes induced by the above-noted method, a medical composition comprising the immunocytes, and a treatment and prevention method using the immunocytes are provided. By co-pulsing antigen-presenting cells with bisphosphonate in addition to the pulse with a disease antigen, the ratio of disease antigen-specific CD8+ CTLs and/or &#x3b3;&#x3b4; T cells and the number of the disease antigen-specific CD8+ CTLs and the &#x3b3;&#x3b4; T cells can be increased, compared with the case where the co-pulse with bisphosphonate is not carried out.

Method for activation treatment of antigen-presenting cell

The present invention provides dendritic cells capable of efficiently activating and/or proliferating &#x3b3;&#x3b4; T-cells in vivo and/or in vitro, pharmaceutical compositions comprising said dendritic cells, therapeutic methods and &#x3b3;&#x3b4; T-cell culture methods utilizing said dendritic cells. By pulsing immature dendritic cells derived from peripheral blood monocytes with a bisphosphonate-based bone metabolism improving drug to enable the cells to activate &#x3b3;&#x3b4; T-cells, and cultivating them with a cell subset containing &#x3b3;&#x3b4; T-cells, &#x3b3;&#x3b4; T-cells can be activated and/or proliferated. This allows for easy proliferation of &#x3b3;&#x3b4; T-cells without burdening a patient, leading to practical applications of immune cell therapies that utilize &#x3b3;&#x3b4; T-cells.

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Tokyo, Japan

Manami Isogai