Merck + Co., Inc.

Manal A Morsy

C Thomas Caskey

Thomas H Rushmore

MingCheng Gu

Ming Cheng Gu

Stephan Kochanek

Karen Richards

Jing Zhang Zhao

Jing Zhoa

Gene therapy can treat obesity in mammals. An obesity regulating gene is delivered to a mammal. Preferably, the gene encodes leptin or a leptin receptor. The protein which is delivered and expressed in vivo is more effective than protein which is injected into the animal.

Gene therapy for obesity

Adenoviral vectors are used to transfer a promoter/reporter gene construct to mammalian cell cultures. The promoter/reporter gene construct is used to determine if a candidate inducing agent has promoter-inducing activity; or can be used to determine if a candidate promoter has activity in the presence of a known inducer.

Adenoviral based promoter assay

Gene therapy can treat obesity in mammals. An adenoviral vector encoding a leptin gene is delivered intravenously to a mammal with a deficiency in functional leptin to decrease weight, decrease serum insulin levels or decrease serum glucose levels.

Gene therapy for leptin deficiency

Growing community of inventors

Blue Bell, PA, United States of America

Manal A Morsy