Kanagawa Academy of Science and Technology

Nippon Sheet Glass Company, Limited

Japan Science and Technology Agency

Kansai Paint Company, Ltd.

Hitachi Plant Technologies, Ltd.

Institute of Microchemical Technology

Manabu Tokeshi

Takehiko Kitamori

Jun Yamaguchi

Akihiko Hattori

Akihide Hibara

Masaya Kakuta

Kazuhiko Nakano

Kenji Miyagawa

Takahide Takadera

Hidekazu Tsudome

Keita Tanaka

Hitoshi Izumida

Kouichi Tsuji

An objective of the present invention is to provide immunoassay microchips in which microstructures of beads having a sufficient reaction area were constructed within microchannels while suppressing flow path resistance, and to provide simple and highly-sensitive immunoassay methods for microsamples. The objective was achieved by immunoassay microchips comprising microchannels with microstructures arranged in at least a portion of the microchannels, the microstructures retaining microbeads uniformly dispersed in photo-cured hydrophilic resins, and the microbeads having a primary antibody immobilized on their surfaces, and by immunoassay methods using the microchips.

Microchips, kits, and methods for immunoassays

For enlarging the application range of samples capable of being treated, decreasing the amount of samples used, preventing deterioration of samples by a change with the passage of time and preventing mixing of samples by diffusion, a micro fluidics system according to the present invention comprises a sample server which stores plural samples and which has sample efflux portions, a microchip for feeding samples to a treating portion through plural sample introducing portions communicating with the sample efflux portions and further through a microchannel, allowing the samples to be subjected to a predetermined treatment, and a sample feeder for feeding the samples stored in the sample server to the sample introducing portions through the sample efflux portions. The sample feeder comprises valves for opening and closing communication paths between the sample efflux portions of the sample server and the sample introducing portions of the microchip and pressurizing devices for pressurizing the samples stored in the sample server and pushing them out into the sample introducing portions in an open condition of the valves.

Micro fluidics system and treating method using same

A plurality of elements can be analyzed simultaneously with high sensitivity using a microchip. The microchip () comprises a substrate (), a channel () formed in the substrate (), and an analyzing part () consisting of a part of flat surface of the substrate (), where the outlet of the channel () is formed as an opening () and measurement object liquid overflowed from the opening () stays on the flat surface of the substrate () to become a sample of analysis. The measurement object liquid is made to overflow as a sample of analysis to the analyzing part () using the microchip () and then the sample of analysis is preferably dried before a primary X-ray is made to enter under conditions of total reflection and fluorescent X-rays are detected.

Microchip and analyzing method and device employing it

An integrated structure of multilayer flow microchannel, which comprises a plurality of microchannels in which parallel multilayer flow that involves the interface of fluids is formed, arranged on various positions of a substrate, wherein each of the multilayer flow microchannels is communicated with another multilayer flow microchannel. A plurality of unit operations can be carried out continuously with high efficiency on a microchip, enabling high-degree microanalysis or precise chemical synthesis using the highly integrated structure of multilayer flow microchannel.

Method of operating an integrated structure of multilayer flow microchannel

A microchemical system is provided, which can improve the working efficiency of the user. In the microchemical system, a plate-shaped elementthat constitutes an optical unithas an optical wave guide path, which acts as an optical path for exciting light and detecting light. An irradiation lensis disposed at an end of the optical wave guide pathdownstream in the direction of travel of the exciting light and the detecting light, and a channelis located downstream of the irradiation lens, through which a liquid containing a sample flows. A detectoris disposed at an end of the plate-shaped elementdownstream of the channeland detects the detecting light for analysis of the sample.

Microchemical system and photothermal conversion spectroscopic analysis method implemented by the system

A small and portable microscope for ultramicroanalysis has an excellent spatial resolution and fixed position analyzing ability. The microscope has at least a part of an excitation light source, a part of a probe light source and a part of a thermal lens microscope optical system arranged integrally in a device body. The device body also includes an analyzing cell and substrates supporting the analyzing cell.

Thermal lens microscope device

It is an object to provide a photothermal conversion spectroscopic analysis method that enables measurement to be carried out with high sensitivity, and a photothermal conversion spectroscopic analysis apparatus that carries out the method. The photothermal conversion spectroscopic analysis apparatus is comprised of an exciting light source, a chopperthat is disposed close to the exciting light sourcein the optical path of exciting light emitted from the exciting light source, a mirrorthat changes the direction of travel of the exciting light, a detecting light source, a dichroic mirrorthat has detecting light from the detecting light sourceincident thereon and makes the exciting light and the detecting light coaxial, a lensthat has a suitable amount of chromatic aberration, and a holderthat holds the lenssuch as to enable adjustment along three axes.

Photothermal conversion spectroscopic analysis method, and photothermal conversion spectroscopic analysis apparatus for carrying out the method

A microchemical system is provided, which can improve the working efficiency of the user and can be designed compact in size. The microchemical system is provided with an optical fiberwith a gradient index rod lensmounted on an end thereof. The lens-possessing optical fiberis comprised of an optical fiberthat transmits exciting light and detecting light in the single mode, and a ferrulefor expanding the outer diameter of the optical fiberto the same value as that of the gradient index rod lens. The gradient index rod lensand the optical fiberare rigidly joined together by means of a sleeve

Growing community of inventors

Kanagawa, Japan

Manabu Tokeshi