Japanese Foundation for Cancer Research

Jichi Medical University

Educational Foundation Jichi Medical University

Manabu Soda

Hiroyuki Mano

Yuichi Ishikawa

Kengo Takeuchi

Eirin Sai

Young L Choi

Polynucleotides which are novel causative genes for cancer are elucidated, and a detection method of the polynucleotides or polypeptides encoded by the polynucleotides, and a kit and a primer set for detection are provided, based on the knowledge gained by the elucidation. In the detection method, a fusion gene comprising part of an SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 gene and part of a ROS1 gene, or a fusion protein encoded by the fusion gene is detected. The primer set or the detection kit comprises a sense primer designed based on a portion encoding SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 and an antisense primer designed based on a portion encoding ROS1.

Detection method for novel ROS1 fusions

Described herein are compositions, kits, and methods for determining whether subjects having cancer(s) positive for ALK mutations are likely to respond to treatment with an ALK inhibitor and/or whether a patient having such cancer(s) is likely to have a relatively slower disease progression. Further described are methods for prognosing a time course of disease in a subject having such cancer.

Identification, assessment, and therapy of cancers with innate or acquired resistance to ALK inhibitors

Growing community of inventors

Tochigi, Japan

Manabu Soda