Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Manabu Shirato

Shigeru Souda

Fumihiro Ozaki

Hitoshi Oinuma

Toshiaki Ogawa

Yasuhiro Kabasawa

Keiji Ishibashi

Satoshi Katayama

Yasutaka Takase

Takashi Hasegawa

Katsuhiro Moriya

Naoto Ishii

Mitsuaki Miyamoto

Osamu Asano

Kazuki Miyazaki

Naoki Yoneda

Ichiro Yoshida

Junichi Kamata

Takao Saeki

Yoshiaki Ohashi

Hiromitsu Yokohama

Yoshinori Sakuma

Shuichi Suzuki

Kazutomi Kusano

Hidenori Seshimo

Hisashi Wakita

Daiya Shimokubo

Futoshi Miyazaki

Mai Saeki, Legal Representative

Tomoko Saeki, Legal Representative

Takao (deceased) Saeki

A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like: wherein R represents hydroxyl, Calkoxy optionally substituted with Calkoxy, or amino optionally substituted with Calkyl.

4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives

The present invention discloses compounds and compositions of formula (I): having inhibitory activity on activation of STAT6, wherein X represents quinoline, isoquinoline, quinazoline or imidazopyridine; Y represents phenyl, piperazine, pyridine, thiophene, thiazole, oxathiazole or oxathiadiazole; and variables Z, n, R, R, Rand Rare as defined in the claims.

Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof

To provide a novel cyclohexane derivative, a cyclohexane derivative is defined by the formula (I) or a pharmacologically acceptable salt thereof: ##STR1## (wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents hydrogen or lower alkyl; R.sup.3 represents optionally substituted aryl or optionally substituted heteroaryl; X represents oxygen or sulfur; and Y represents a group represented by the formula: ##STR2## or the like). The compound of the present invention is useful as a preventive and therapeutic agent for diseases against which a potassium channel opening action is efficacious.

Cyclohexane derivatives

To provide a cyclohexane derivative defined by the formula (I) or a pharmacologically acceptable salt thereof: ##STR1## (wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents hydrogen or lower alkyl; R.sup.3 represents optionally substituted aryl or optionally substituted heteroaryl; X represents oxygen or sulfur; and Y represents a group represented by the formula: ##STR2## or the like). The compound of the present invention is useful as a preventive and therapeutic agent for diseases against which a potassium channel opening action is efficacious.

Growing community of inventors

Tsukuba, Japan

Manabu Shirato