Shimadzu Corporation

Gl Sciences, Inc.

Manabu Shimomura

Shuichi Kawana

Akira Aono

Masaru Nishiguchi

Hiroto Itoi

Akira Suzuki

Yosuke Sato

Takeshi Uchida

Masahiro Furuno

Yoshiyuki Takei

Hiroshi Yamauchi

Shinji Fukumoto

Tadashi Mimura

Kaori Tanaka

Ryo Kageyama

A mass spectrometry device includes a vacuum container in which an ionizer, a mass separator and a detector are arranged, and includes an opening-closing portion that is provided at the vacuum container and switches between a locked state of being locked in a close state and an unlocked state by a difference in pressure between inside and outside of the vacuum container, and a cooling gas introducer that introduces a cooling gas for cooling the ionizer into the vacuum container such that the opening-closing portion is kept in the locked state.

Mass spectrometry device and mass spectrometry method

An analytical device, includes: an ionization unit that ionizes carrier gas introduced into the separation column; a mass separation unit that mass-separates ions generated in the ionization unit; a detection unit that detects the ions mass-separated by the mass separation unit in amplification with a predetermined multiplication factor, and outputs a detection signal; an analysis unit that analyzes the detection signal having been output from the detection unit; and an adjustment unit performs an adjustment of the multiplication factor of the detection unit and/or voltage applied to an electrode of an ion transport system of the mass separation unit based on magnitude of the detection signal corresponding to the carrier gas detected by the detection unit.

Analytical device, analytical method and program

Measurement of a standard sample is repeated under control of an analysis control unit () while a CD voltage applied to a conversion dynode () of a detection unit () is gradually changed by a CD voltage adjustment unit (). Then, every time a measured mass spectrum is obtained, a spectrum pattern determination unit () determines whether a pattern of the measured mass spectrum matches a pattern of a standard mass spectrum of a standard sample in a compound database (), and determines the CD voltage at the time of being regarded as matching to be the set value. When the pattern of the mass spectrum is adjusted by changing the voltage applied to the ion lens (), performance such as sensitivity is likely to be unstable due to stain on the lens electrode or the like, but since the detection unit () is unlikely to be affected by such a stain, unstable performance can be avoided.

Quadrupole mass spectrometer

In a chromatogram mass spectrometer's data processing system, if the intensity of a target peak originating from a target component at a target mass-to-charge ratio is equal to or higher than a threshold, the mass-to-charge ratio of a peak having a signal intensity lower than the threshold on the mass spectrum corresponding to the point in time where the target peak appears is designated as a correction mass-to-charge ratio. A mass spectrum at a point in time in the target peak where the signal intensity does not exceed the threshold is acquired. A sensitivity factor is calculated by dividing the strength at the target mass to-charge ratio on this mass spectrum by the strength at the correction mass to-charge ratio on the same spectrum. A mass chromatogram at the correction mass-to-charge ratio is created. This mass chromatogram is multiplied by the sensitivity factor to create a corrected mass chromatogram.

Data processing system and program for chromatograph mass spectrometer

In a device adjustment process, when a solenoid valve is opened, a gas resulting from vaporization of PFTBA held in a container is drawn into an ion source, a relationship between ambient temperature and a correction coefficient for actual signal values is experimentally determined beforehand. In an actual adjustment process, an ambient temperature acquirer reads the ambient temperature and refers to the correction information to determine the correction coefficient corresponding to the ambient temperature at that moment. A signal value corrector multiplies an actually measured peak area value by the correction coefficient to correct the actual signal value. A device adjustment controller adjusts a voltage applied to an ion detector so that the corrected actual signal value matches with a reference signal value. The voltage applied to the ion detector can be thereby adjusted so that the detector has the same level of gain independent of the ambient temperature.

Mass spectrometer

The present invention provides a method and apparatus for rapidly extracting the analyte existing in the liquid phase in analyzing an analyte 'having a large partition coefficient in gas-liquid equilibrium', 'having a high water solubility', or &#x201c;having a low olfactory threshold&#x201d; by a gas-liquid contact extraction method, and further provides, a method and apparatus for unmanned continuous sample introduction of the analyte to a GC or the like for a long time. In the present invention, using a gas-liquid contact extractor to which a sample liquid is continuously introduced from above and a purge gas from beneath, the analyte in the sample liquid is extracted by gas-liquid contact between the sample liquid and the purge gas. A discharge pipe is connected to the bottom of the gas-liquid contact extractor, the pipe having a liquid sump through which the sample liquid is discharged, while blocking the outflow of the purge gas from the liquid sump.

Gas-liquid contact extraction method and apparatus

Flanges () of an attachment plate () integrally combined with an ion detector () are fixed to an inner surface of a vacuum chamber () via cushioning members (), such as O-rings. Although the vacuum chamber () mechanically vibrates due to a turbomolecular pump attached to it, this vibration is absorbed by the cushioning members (), whereby the vibration of the ion detector () is suppressed. As a result, the noise which occurs with a vibration of the ion detector () and is superposed on the detection signal is reduced. Thus, the quality of the detection signal can be improved by a simple and inexpensive structure.

A headspace sample introduction device which collects a sample gas from a sample container and introduces the gas into a predetermined analyzer is provided. The device includes a sample traycapable of holding at least one sample containerstoring a liquid sample or a solid sample, a heating meansfor heating at least one sample containertaken from the sample tray, a sample-gas collecting meansfor collecting a sample gas from the upper space in the sample containerheld in the heating means, and a cooling transfer meansfor keeping and cooling at least one sample containertaken from the heating meansand returning the cooled sample containerto the sample tray. Since the headspace sample introduction device can return the heated sample containersto the sample trayafter they are cooled with the cooling transfer means, the hot sample containers can be assuredly prevented from contacting the user.

Headspace sample introduction device

Elements are arranged so that a straight ion-beam axis extending from an ion source through a first ion lens and a front-stage quadrupole mass filter and a straight ion-beam axis extending through the ion guide in a collision cell and a rear-stage quadrupole mass filter obliquely intersect with each other at a predetermined angle in a space between the front-stage quadrupole mass filter and the collision cell. Metastable helium molecules generated in the ion source may pass through the front-stage quadrupole mass filter but will be removed before reaching the exit of the collision cell. On the other hand, precursor ions which have passed through the front-stage quadrupole mass filter are made to bend along an inflected ion-beam axis under the influence of a direct-current electric field created by an entrance ion lens, to be efficiently introduced into the collision cell.

Triple quadrupole mass spectrometer

An electrically conductive heat-blocking platewith an openingfor allowing thermions to pass through is provided between a filamentwhose temperature can be as high as 2000&#xb0; to 3000&#xb0; C., and an ionization chamber. The heat-blocking plateis thermally connected via an aluminum blockto a heater for maintaining the ionization chamberwithin a range temperature from 200&#xb0; to 300&#xb0; C., and also electrically set at a ground potential, which is approximately equal to the potential of the ionization chamberThe heat-blocking plateblocks the radiation heat that the filamentemits when energized. Thus, the wall of the ionization chamberis prevented from being locally heated to an abnormally high temperature. As a result, the inner space of the ionization chamberis maintained at an approximately uniform temperature, and the noise due to the decomposition of a metallic material by abnormal heating is prevented. The heat-blocking platealso prevents a thermion-accelerating electric field from penetrating through an electron injection portinto the ionization chamberand impeding the extraction of ions produced within the ionization chamber. Thus, the ion extraction efficiency is also improved.

A filamentfor generating thermions is remotely located from an ionization chamberso that a thermion-accelerating electric field created by a potential difference between the filamentand the ionization chamberis prevented from penetrating through an electron injection portinto the ionization chamber. This design eliminates the disturbance of an ion-extracting electric field created within the ionization chamberby a voltage applied to lens electrodes, thus enabling ions produced within the ionization chamberto be efficiently extracted and transported to a mass analyzer located at the subsequent stage. As a result, the level of detection signals of a detector is increased, so that the mass analysis can be performed with high sensitivity.

An interface placed between a gas chromatograph part and a mass spectrometer part of a gas chromatograph mass spectrometer for allowing one or two columns to pass air-tightly from the gas chromatograph part to the mass spectrometer part. The interface includes: a heat-retention block having a small-diameter hole allowing two columns to pass through; a single-hole ferrule having a small-diameter hole allowing a single column to pass through; and a two-hole ferrule having two small-diameter holes allowing two columns to respectively pass through. An adapter is placed between the heat-retention block and the two-column nut. It includes a long large-diameter opening allowing two columns passing through the two-hole ferrule to converge on the small-diameter hole of the heat-retention block. The interface also includes a single-column nut for pressing the single-hole ferrule to the heat-retention block; and a two-column nut for pressing the two-hole ferrule to the adapter.

Gas chromatograph mass spectrometer

In a mass spectrometer, an ion of a sample gas is produced in an ion source by colliding the gas with an electron beam, and is introduced into a magnetic field or an electric field. The ion is separated based on the mass number, and the sample is analyzed from a mass spectrum. The ion source has an electrode made of stainless steel, which is baked at a temperature in a range from 200&#xb0; C. to 700&#xb0; C. in an air atmosphere.

Method of preparing and reconditioning an electrode of mass spectrometer

First, normal calibration is executed by introducing a standards sample to an MS portion, thereafter, an adjusting sample is introduced to a GC portion, and a mass spectrum is acquired by executing mass spectrometry by the MS portion with regard to an object substance separated by a column. A data processing portion compares a measured mass spectrum and a standard spectrum and modifies a standard spectrum constituting a target in executing calibration by using a standard sample from the result. The standard spectrum modified in this way is reflected with an error factor of a dispersion in a purity of the standard sample or the like and therefore, when recalibration of the MS portion using the standard sample is executed by constituting a target by the modified standard spectrum, a difference among apparatus is resolved.

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Kyoto, Japan

Manabu Shimomura