Kowa Company Limited

Manabu Shibasaki

Seiichi Sato

Hiroyuki Ishiwata

Mototsugu Kabeya

Soichi Oda

Makoto Suda

Hiroshi Nakao

Takao Nagoya

Yukio Hattori

Masami Shiratsuchi

Hiromichi Shigyo

Masahiro Tamura

Tetsuya Ishikawa

Hajime Yamada

Takahiro Kitamura

Takeshi Doi

Shunji Takemura

Yoshiharu Miyake

Masanori Ashikawa

Takatoshi Ozawa

Yuichiro Tabunoki

Akiyasu Kouketsu

Ryota Shigemi

To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sj&#xf6;gren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.

Pyridine-3-carboxyamide derivative

A bis(5-aryl-2-pyridyl) compound represented by formula (1) or a salt thereof: wherein A is a substituted or unsubstituted aromatic hydrocarbyl group or a substituted or unsubstituted aromatic heterocyclic group, and X is a group selected from the group consisting of moieties having formulas (2) to (5): wherein, in formula (2), m is an integer of 1 or 2; in formula (3), n is an integer of 1 to 6; and in formula (4), R is hydrogen or a lower alkyl group and p is an integer of 1 to 6.

Bis(5-aryl-2-pyridyl) derivatives

A bis(2-aryl-5-pyridyl) compound having formula (1) or a salt thereof:wherein A is a substituted or unsubstituted aromatic hydrocarbon group, and X is a substituent having one of the following formulas (2) to (4):wherein, in formula (2), Ris a hydrogen atom or a di(lower alkyl)amino(lower alkyl) group, and m is an integer of 1 or 2; in formula (3), Yand Yeach is a nitrogen atom or a CH group, and n is 0 or an integer of 1 to 6; in formula (4), Rand Reach is a hydrogen atom or a lower alkyl group, Z represents a single bond, a substituted methylene group, a substituted imino group, an oxygen atom or a cycloalkylene group, and p and q each is 0 or an integer of 1 to 6.

Bis(2-aryl-5-pyridyl) derivatives

Diamide compound and medicine containing the same

Cyclic amide compound

Diamide compounds and compositions containing the same

Cyclic amide compounds

Diamide compound and drugs containing the same

The present invention relates to compounds represented by the following general formula (1):

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Tsukuba, Japan

Manabu Shibasaki