Asahi Kasei Chemicals Corporation

Otsuka Chemical Co., Ltd.

Okayama University

Hokko Chemical Industry Co., Ltd.

Manabu Kuroboshi

Hideo Tanaka

Yutaka Kameyama

Takae Yamada

Tomotake Yano

Masakatsu Hoshino

Hiromu Kawakubo

Syoichi Tateyama

Disclosed is a process for producing a phosphine derivative from a phosphine oxide derivative, which comprises the following steps: (I) mixing a phosphine oxide derivative represented by formula (1) with a chlorinating agent in a polar organic solvent to cause the reaction between these components; and (II-1) adding a salt of a metal having an ionization tendency equal to or lower than that of aluminum to the reaction mixture and carrying out the reductive reaction in the presence of aluminum or (II-2) subjecting the reaction mixture to electrolytic reduction, thereby producing a phosphine derivative represented by formula (2). ArRP&#x2550;O (1) ArRP (2) In formulae (1) and (2), Ar represents an aryl group such as a phenyl group, a phenyl group having a substituent, a heteroaromatic ring group, and a heteroaromatic ring group having a substituent; R represents an aliphatic hydrocarbon group or an aliphatic hydrocarbon group having a substituent; and n represents an integer of 0 to 3.

Process for production of phosphine derivative from phosphine oxide derivative

The present invention provides a method by which a 6-hydroxyethyl penam compound represented by General Formula (2) below can be produced with a high selectivity: wherein R represents a hydrogen atom or a protective group for carboxylic acid and Xrepresents a halogen atom; wherein R and Xare the same as above, and Xrepresents a halogen atom;

Method for producing 6-hydroxyethylpenam compound

Growing community of inventors

Okayama, Japan

Manabu Kuroboshi